Bacterial Modulation of Fc Effector Functions

Research output: Chapter in Book/Report/Conference proceedingBook chapter

Abstract

Immunoglobulins (Igs, antibodies) are key players in adaptive immunity, and pathways mediated through the effector Fc portion of Ig are instrumental in controlling bacterial infections. Therefore, it is not very surprising that bacterial pathogens and commensals through co-evolution with their hosts have learned many tricks to interfere with Fc effector functions. In this chapter, we describe three principally different bacterial strategies to interfere with immunoglobulins: Specific Ig binding, specific or unspecific Ig protelolysis, and, finally, specific and unspecific hydrolysis of functionally important carbohydrates on the immunoglobulins. Elucidating these bacterial immune evasion mechanism evidences bacteria-host co-evolution and provides insight into fundamental aspects of human adaptive immunity and pathogenesis of infection.

Details

Authors
Organisations
External organisations
  • Aarhus University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Microbiology in the medical area
  • Infectious Medicine
  • Immunology in the medical area

Keywords

  • Glycan hydrolysis, Glycosylation, Immune evasion, Immunoglobulin, Immunoglobulin binding, Proteases
Original languageEnglish
Title of host publicationAntibody Fc
Subtitle of host publicationLinking Adaptive and Innate Immunity
PublisherElsevier Inc.
Chapter18
Pages317-332
Number of pages16
ISBN (Print)9780123948021
Publication statusPublished - 2013 Sep 1
Publication categoryResearch
Peer-reviewedYes