Base-catalyzed intramolecular condensation of tokinolide B.

Research output: Contribution to journalArticle


The novel pentacyclic compound cyclotokinolide B was obtained from the natural phthalide tokinolide B under basic conditions, via the chemoselective -enol lactone opening followed by a Michael addition of the generated carbanion to the enone and subsequent equilibration. This result confirms that some dimeric phthalides undergo intramolecular cyclizations in basic media.


  • B Quiroz-García
  • L Hernández
  • R A Toscano
  • Olov Sterner
  • G Delgado
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry
Original languageEnglish
Pages (from-to)2509-2512
JournalTetrahedron Letters
Issue number12
Publication statusPublished - 2003
Publication categoryResearch

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)