Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study

Research output: Contribution to journalArticle


Background: Results from several cohort and case-control studies suggest a protective association between current alcohol intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain unanswered. Methods: The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid carcinoma was examined in the European Prospective Investigation into Cancer and Nutrition. Among 477 263 eligible participants (70% women), 556 (90% women) were diagnosed with differentiated thyroid carcinoma over a mean follow-up of 11 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards models. Results: Compared with participants consuming 0.1-4.9 g of alcohol per day at recruitment, participants consuming 15 or more grams (approximately 1-1.5 drinks) had a 23% lower risk of differentiated thyroid carcinoma (HR = 0.77; 95% CI = 0.60-0.98). These findings did not differ greatly when analyses were conducted for lifetime alcohol consumption, although the risk estimates were attenuated and not statistically significant anymore. Similar results were observed by type of alcoholic beverage, by differentiated thyroid carcinoma histology or according to age, sex, smoking status, body mass index and diabetes. Conclusions: Our study provides some support to the hypothesis that moderate alcohol consumption may be associated with a lower risk of papillary and follicular thyroid carcinomas.


  • Abhijit Sen
  • Konstantinos K. Tsilidis
  • Naomi E. Allen
  • Sabina Rinaldi
  • Paul N. Appleby
  • Julie A. Schmidt
  • Christina C. Dahm
  • Kim Overvad
  • Anne Tjonneland
  • Agnetha L. Rostgaard-Hansen
  • Francoise Clavel-Chapelon
  • Laura Baglietto
  • Marie-Christine Boutron-Ruault
  • Tilman Kuehn
  • Verena A. Katze
  • Heiner Boeing
  • Antonia Trichopoulou
  • Christos Tsironis
  • Pagona Lagiou
  • Domenico Palli
  • Valeria Pala
  • Salvatore Panico
  • Rosario Tumino
  • Paolo Vineis
  • H. B. (as) Bueno-de-Mesquita
  • Petra H. Peeters
  • Anette Hjartaker
  • Eiliv Lund
  • Elisabete Weiderpass
  • J. Ramon Quiros
  • Antonio Agudo
  • Maria-Jose Sanchez
  • Larraitz Arriola
  • Diana Gavrila
  • Aurelio Barricarte Gurrea
  • Joakim Hennings
  • Maria Sandstrom
  • Isabelle Romieu
  • Pietro Ferrari
  • Raul Zamora-Ros
  • Kay-Tee Khaw
  • Nicholas J. Wareham
  • Elio Riboli
  • Marc Gunter
  • Silvia Franceschi
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Public Health, Global Health, Social Medicine and Epidemiology
  • Cancer and Oncology


  • alcohol consumption, thyroid carcinoma, prospective study, lifetime, exposure
Original languageEnglish
Pages (from-to)840-847
JournalBritish Journal of Cancer
Issue number5
Publication statusPublished - 2015
Publication categoryResearch