Basic helix-loop-helix proteins expressed during early embryonic organogenesis.

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Basic helix-loop-helix proteins expressed during early embryonic organogenesis. / Hjalt, Tord.

In: International Review of Cytology, Vol. 236, 2004, p. 251-280.

Research output: Contribution to journalReview article

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TY - JOUR

T1 - Basic helix-loop-helix proteins expressed during early embryonic organogenesis.

AU - Hjalt, Tord

PY - 2004

Y1 - 2004

N2 - The basic helix–loop–helix proteins form a special group of transcription factors unique for the eukaryotic organisms. They are crucial for the embryonic development of many fundamental organ systems such as muscle, heart, central nervous system, hematopoiteic system, and many others. They are very flexible in terms of regulating transcription in that they can either promote or repress transcription, and do so in many different ways. Basic helix–loop–helix proteins can form homo- or heterodimers with other members of the group, and are subject to post-transcriptional modifications. In this review, an overview of basic helix–loop–helix protein classification, biochemical function, and examples of past and recent advances in our understanding of embryonic development are presented, with emphasis on the vertebrate muscle, heart, brain, and eye.

AB - The basic helix–loop–helix proteins form a special group of transcription factors unique for the eukaryotic organisms. They are crucial for the embryonic development of many fundamental organ systems such as muscle, heart, central nervous system, hematopoiteic system, and many others. They are very flexible in terms of regulating transcription in that they can either promote or repress transcription, and do so in many different ways. Basic helix–loop–helix proteins can form homo- or heterodimers with other members of the group, and are subject to post-transcriptional modifications. In this review, an overview of basic helix–loop–helix protein classification, biochemical function, and examples of past and recent advances in our understanding of embryonic development are presented, with emphasis on the vertebrate muscle, heart, brain, and eye.

KW - Development

KW - Organogenesis

KW - Embryogenesis

KW - Basic helix–loop–helix

KW - bHLH

KW - Differentiation

U2 - 10.1016/S0074-7696(04)36006-7

DO - 10.1016/S0074-7696(04)36006-7

M3 - Review article

VL - 236

SP - 251

EP - 280

JO - International Review of Cell and Molecular Biology

JF - International Review of Cell and Molecular Biology

SN - 1937-6448

ER -