BB rat diabetes susceptibility and body weight regulation genes colocalize on Chromosome 2

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BB rat diabetes susceptibility and body weight regulation genes colocalize on Chromosome 2. / Klaff, Lindy S.; Koike, George; Jiang, Jianjie; Wang, Yanling; Bieg, Sabine; Pettersson, Anna; Lander, Eric; Jacob, Howard; Lernmark, Ake.

In: Mammalian Genome, Vol. 10, No. 9, 30.09.1999, p. 883-887.

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Harvard

Klaff, LS, Koike, G, Jiang, J, Wang, Y, Bieg, S, Pettersson, A, Lander, E, Jacob, H & Lernmark, A 1999, 'BB rat diabetes susceptibility and body weight regulation genes colocalize on Chromosome 2', Mammalian Genome, vol. 10, no. 9, pp. 883-887. https://doi.org/10.1007/s003359901108

APA

Klaff, L. S., Koike, G., Jiang, J., Wang, Y., Bieg, S., Pettersson, A., Lander, E., Jacob, H., & Lernmark, A. (1999). BB rat diabetes susceptibility and body weight regulation genes colocalize on Chromosome 2. Mammalian Genome, 10(9), 883-887. https://doi.org/10.1007/s003359901108

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Klaff, Lindy S. ; Koike, George ; Jiang, Jianjie ; Wang, Yanling ; Bieg, Sabine ; Pettersson, Anna ; Lander, Eric ; Jacob, Howard ; Lernmark, Ake. / BB rat diabetes susceptibility and body weight regulation genes colocalize on Chromosome 2. In: Mammalian Genome. 1999 ; Vol. 10, No. 9. pp. 883-887.

RIS

TY - JOUR

T1 - BB rat diabetes susceptibility and body weight regulation genes colocalize on Chromosome 2

AU - Klaff, Lindy S.

AU - Koike, George

AU - Jiang, Jianjie

AU - Wang, Yanling

AU - Bieg, Sabine

AU - Pettersson, Anna

AU - Lander, Eric

AU - Jacob, Howard

AU - Lernmark, Ake

PY - 1999/9/30

Y1 - 1999/9/30

N2 - The genetic etiology of Type 1 (insulin-dependent) diabetes mellitus is complicated by the apparent presence of several diabetes susceptibility genetic regions. Type I diabetes in the inbred BioBreeding (BB) rat closely resembles the human disorder and was previously shown to involve two genes: the lymphopenia (lyp) region on Chromosome (Chr) 4 and RT1(u) in the major histocompatibility complex (MHC) on Chr 20. In addition, a segregation analysis of an F2 intercross between the diabetes-prone congenic BB DR(lyp/lyp,u/u) and F344(+/+,lv/lv) rats indicated that at least one more genetic factor was responsible for Type 1 diabetes. In this study, we generated F2N2 progeny in a cross between non-diabetic F2(DR)lyp/lyp,u/u) X F344)(lyp/lyp,u/u) and diabetic DR(lyp/lyp,u/u) rats. In a subsequent total genome scan, a third factor was mapped to the 21.3-cM region on Chr 2 between D2Mit14 and D2Mit15 (peak LOD score 4.7 with 67% penetrance). Interestingly, the homozygosity of the BB allele (b/b) for the Chr 2 region was significantly associated with a greater weight reduction after fasting than the homozygosity of the F344 allele (f/f, p < 0.008). In conclusion, the development of Type I diabetes in the congenic DR(lyp/lyp) rat is controlled by at least three genes: lymphopenia, MHC, and a third factor that may play a role in metabolism and body weight regulation.

AB - The genetic etiology of Type 1 (insulin-dependent) diabetes mellitus is complicated by the apparent presence of several diabetes susceptibility genetic regions. Type I diabetes in the inbred BioBreeding (BB) rat closely resembles the human disorder and was previously shown to involve two genes: the lymphopenia (lyp) region on Chromosome (Chr) 4 and RT1(u) in the major histocompatibility complex (MHC) on Chr 20. In addition, a segregation analysis of an F2 intercross between the diabetes-prone congenic BB DR(lyp/lyp,u/u) and F344(+/+,lv/lv) rats indicated that at least one more genetic factor was responsible for Type 1 diabetes. In this study, we generated F2N2 progeny in a cross between non-diabetic F2(DR)lyp/lyp,u/u) X F344)(lyp/lyp,u/u) and diabetic DR(lyp/lyp,u/u) rats. In a subsequent total genome scan, a third factor was mapped to the 21.3-cM region on Chr 2 between D2Mit14 and D2Mit15 (peak LOD score 4.7 with 67% penetrance). Interestingly, the homozygosity of the BB allele (b/b) for the Chr 2 region was significantly associated with a greater weight reduction after fasting than the homozygosity of the F344 allele (f/f, p < 0.008). In conclusion, the development of Type I diabetes in the congenic DR(lyp/lyp) rat is controlled by at least three genes: lymphopenia, MHC, and a third factor that may play a role in metabolism and body weight regulation.

U2 - 10.1007/s003359901108

DO - 10.1007/s003359901108

M3 - Article

C2 - 10441739

AN - SCOPUS:0032878618

VL - 10

SP - 883

EP - 887

JO - Mammalian Genome

JF - Mammalian Genome

SN - 1432-1777

IS - 9

ER -