Benzochromenes from the roots of Bourreria pulchra

Research output: Contribution to journalArticle


Two new benzochromenes, (6,6-dimethyl-2-methoxy-6H-benzo[c]chromen-9-yl)methanol (1), and 2-methoxy-6,6-dimethyl-6H-benzo[c]chromen-9-carbaldehyde (2), together with several already known metabolites, were isolated from the root extract of Bourreria pulchra (Boraginaceae). The structures of 1 and 2 were established on the basis of their spectroscopic data. Both were assayed for in vitro antiprotozoan activity, and especially 1 was found to possess significant activity against Leishmania mexicana and Trypanosoma cruzi parasites (IC50 4.6 mu g/mL and 7.5 mu g/mL, respectively). (C) 2009 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.


  • Gilda J. Erosa-Rejon
  • Alejandro Yam-Puc
  • Manuel J. Chan-Bacab
  • Alberto Gimenez-Turbax
  • Efrain Salamanca
  • Luis M. Pena-Rodriguez
  • Olov Sterner
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry


  • Bourreria pulchra, Boraginaceae, Benzochromene, Antiprotozoal, Leishmania mexicana, Trypanosoma cruzi
Original languageEnglish
Pages (from-to)9-12
JournalPhytochemistry Letters
Issue number1
Publication statusPublished - 2010
Publication categoryResearch

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240)