Beta1 integrin is not essential for hematopoiesis but is necessary for the T cell-dependent IgM antibody response.

Research output: Contribution to journalArticle

Abstract

Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunization with a T cell-dependent antigen resulted in virtually no IgM production and an increased secretion of IgG in mutant mice, while the response to a T cell-independent type 2 antigen showed decreases in both IgM and IgG. These data suggest that beta1 integrins are necessary for the primary IgM antibody response.

Details

Authors
  • Cord Brakebusch
  • Simon Fillatreau
  • Alexandre J Potocnik
  • Gerd Bungartz
  • Patricia Wilhelm
  • Marcus Svensson Frej
  • Phil Kearney
  • Heinrich Körner
  • David Gray
  • Reinhard Fässler
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Immunology in the medical area

Keywords

  • CD29 : immunology, Antigens, CD29 : genetics, Hematopoiesis : genetics, Gene Expression Regulation : immunology, Gene Deletion, B-Lymphocytes : immunology, Immunoglobulin M : biosynthesis, Immunoglobulin M : genetics, Immunoglobulin M : immunology, Mice, Support, Non-U.S. Gov't, T-Lymphocytes : immunology, Antibody Formation : immunology, Animal, Antibody Formation : genetics
Original languageEnglish
Pages (from-to)465-477
JournalImmunity
Volume16
Issue number3
Publication statusPublished - 2002
Publication categoryResearch
Peer-reviewedYes

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Pathology, (Lund) (013030000), Eosinophil Biology (013210067)