beta(1) integrins are not required for the maintenance of lymphocytes within intestinal epithelia.

Research output: Contribution to journalArticle

Abstract

b1 integrins are thought to play a central role in maintaining lymphocytes within
mucosal epithelia via their interactions with extracellular matrix proteins and
subepithelial cellular components within and underlying the basement membrane.
In the current study type a (CD8abTCRab) and type b (CD8aaTCRcd and
CD8aaTCRab) intraepithelial lymphocyte (IEL) subsets within the mouse small
intestine were found to express functional b1 integrin and the b1 integrin a chain
partners a1, a2, and a4. Using inducible b1 integrin-knockout bone marrow-chimeric
mice we demonstrate that IEL expression of a1 and a2 but not a4 is dependent on
expression of the b1 chain. Importantly, deletion of the b1 chain in IEL did not alter the
number or composition of lymphocytes within the intestinal epithelium. Thus, while IEL
express functional b1 integrins, these are not required to maintain lymphocytes within
intestinal epithelia. This result is discussed in the light of conventional views of
intestinal lymphocyte homing and localization.

Details

Authors
  • Jan Marsal
  • Cord Brakebusch
  • Gerd Bungartz
  • Reinhard Fässler
  • William Agace
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Immunology in the medical area

Keywords

  • T lymphocytes, Adhesion molecules, Mucosa
Original languageEnglish
Pages (from-to)1805-1811
JournalEuropean Journal of Immunology
Volume35
Issue number6
Publication statusPublished - 2005
Publication categoryResearch
Peer-reviewedYes