Beyond Survival - Cognition after Pediatric Brain Tumor

Research output: ThesisDoctoral Thesis (compilation)

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Beyond Survival - Cognition after Pediatric Brain Tumor. / Tonning Olsson, Ingrid.

Lund University, Faculty or Social Sciences, Department of Psychology, 2015. 100 p.

Research output: ThesisDoctoral Thesis (compilation)

Harvard

APA

Tonning Olsson, I. (2015). Beyond Survival - Cognition after Pediatric Brain Tumor. Lund University, Faculty or Social Sciences, Department of Psychology.

CBE

Tonning Olsson I. 2015. Beyond Survival - Cognition after Pediatric Brain Tumor. Lund University, Faculty or Social Sciences, Department of Psychology. 100 p.

MLA

Tonning Olsson, Ingrid Beyond Survival - Cognition after Pediatric Brain Tumor Lund University, Faculty or Social Sciences, Department of Psychology. 2015.

Vancouver

Tonning Olsson I. Beyond Survival - Cognition after Pediatric Brain Tumor. Lund University, Faculty or Social Sciences, Department of Psychology, 2015. 100 p.

Author

Tonning Olsson, Ingrid. / Beyond Survival - Cognition after Pediatric Brain Tumor. Lund University, Faculty or Social Sciences, Department of Psychology, 2015. 100 p.

RIS

TY - THES

T1 - Beyond Survival - Cognition after Pediatric Brain Tumor

AU - Tonning Olsson, Ingrid

N1 - Defence details Date: 2015-11-10 Time: 13:15 Place: LUX aula, Helgonavägen 3 External reviewer(s) Name: Smedler, Ann-Charlotte Title: Professor Affiliation: Psykologiska Institutionen, Stockholms Universitet ---

PY - 2015

Y1 - 2015

N2 - Background: Pediatric Brain Tumor (PBT) survivors suffer from cognitive sequelae, especially within the areas of cognitive tempo, attention, executive function and memory. The cognitive difficulties are often accentuated over the years, but knowledge about the long term trajectory is still scarce. Aim: The aim of this thesis was to examine cognitive sequelae after Pediatric Brain Tumor (PBT); risk factors, common difficulties, development and neuroimaging correlates. Methods: In study I, data from medical logs were used to examine characteristics of the patients who got access to neuropsychological services, compared to those who did not. In study II, data from 70 neuropsychological assessments were used to describe common cognitive impairments and to find risk factors. In study III, patients were invited to a follow-up study 10-13 years after diagnosis. Neuropsychological and neuroimaging data were collected and the two were compared. In study IV, longitudinal cognitive data from 173 patients were analyzed in order to describe development over time and to find risk factors for a negative development. Results: Study I: There were few differences between referred and non-referred patients. Study II: Patients had generally suppressed IQ and difficulties with executive function, memory, cognitive processing speed and attention. Risk factors were Whole-Brain Radiation Therapy (WBRT), large tumors, young age at diagnosis and male sex. Study III: Radiated as well as non-radiated patients had white matter abnormalities. Correlation between neuroimaging and cognition was low when group based statistics were used, but increased when a personalized method was used. Study IV: Most cognitive abilities showed a decline in age related scores over time unconsidered treatment given. Risk factors for impaired cognitive function at diagnosis were: male sex, WBRT, supratentorial lateral tumor, young age at diagnosis, larger tumor size and treatment with chemotherapy. Conclusions: A systematic neuropsychological follow-up is important. Risk factors for cognitive impairment and IQ decline are WBRT, large tumors, young age at diagnosis, male sex, supratentorial lateral tumor, and treatment with chemotherapy. A decline in IQ after PBT is common, unconsidered treatment given. Personalized methods of research would contribute significantly to our understanding of cognitive sequelae after PBT and its relation to neuroimaging.

AB - Background: Pediatric Brain Tumor (PBT) survivors suffer from cognitive sequelae, especially within the areas of cognitive tempo, attention, executive function and memory. The cognitive difficulties are often accentuated over the years, but knowledge about the long term trajectory is still scarce. Aim: The aim of this thesis was to examine cognitive sequelae after Pediatric Brain Tumor (PBT); risk factors, common difficulties, development and neuroimaging correlates. Methods: In study I, data from medical logs were used to examine characteristics of the patients who got access to neuropsychological services, compared to those who did not. In study II, data from 70 neuropsychological assessments were used to describe common cognitive impairments and to find risk factors. In study III, patients were invited to a follow-up study 10-13 years after diagnosis. Neuropsychological and neuroimaging data were collected and the two were compared. In study IV, longitudinal cognitive data from 173 patients were analyzed in order to describe development over time and to find risk factors for a negative development. Results: Study I: There were few differences between referred and non-referred patients. Study II: Patients had generally suppressed IQ and difficulties with executive function, memory, cognitive processing speed and attention. Risk factors were Whole-Brain Radiation Therapy (WBRT), large tumors, young age at diagnosis and male sex. Study III: Radiated as well as non-radiated patients had white matter abnormalities. Correlation between neuroimaging and cognition was low when group based statistics were used, but increased when a personalized method was used. Study IV: Most cognitive abilities showed a decline in age related scores over time unconsidered treatment given. Risk factors for impaired cognitive function at diagnosis were: male sex, WBRT, supratentorial lateral tumor, young age at diagnosis, larger tumor size and treatment with chemotherapy. Conclusions: A systematic neuropsychological follow-up is important. Risk factors for cognitive impairment and IQ decline are WBRT, large tumors, young age at diagnosis, male sex, supratentorial lateral tumor, and treatment with chemotherapy. A decline in IQ after PBT is common, unconsidered treatment given. Personalized methods of research would contribute significantly to our understanding of cognitive sequelae after PBT and its relation to neuroimaging.

KW - Pediatric Brain Tumor

KW - Cognition

KW - Late sequelae

KW - Cranial Radiation Therapy

KW - Neuropsychology

M3 - Doctoral Thesis (compilation)

SN - 978-91-7623-488-4 (printed version)

SN - 978-91-7623-489-1 (pdf)

PB - Lund University, Faculty or Social Sciences, Department of Psychology

ER -