Bioactive alkenylphenols from Piper obliquum.

Research output: Contribution to journalArticle


Various parts of Piper obliquum Ruíz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappaB activity by targeting early events in the TNFalpha-induced NF-kappaB inflammatory pathway, which may explain the effects reported for the traditional use of the plant.


  • Carola Valdivia
  • Nieves Marquez
  • John Eriksson
  • Antonio Vilaseca
  • Eduardo Muñoz
  • Olov Sterner
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Organic Chemistry
  • Industrial Biotechnology
Original languageEnglish
Pages (from-to)4120-4126
JournalBioorganic & Medicinal Chemistry
Issue number7
Publication statusPublished - 2008
Publication categoryResearch

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Applied Microbiology (LTH) (011001021), Organic chemistry (S/LTH) (011001240)