Bioactive alkenylphenols from Piper obliquum.

Research output: Contribution to journalArticle

Standard

Bioactive alkenylphenols from Piper obliquum. / Valdivia, Carola; Marquez, Nieves; Eriksson, John; Vilaseca, Antonio; Muñoz, Eduardo; Sterner, Olov.

In: Bioorganic & Medicinal Chemistry, Vol. 16, No. 7, 2008, p. 4120-4126.

Research output: Contribution to journalArticle

Harvard

Valdivia, C, Marquez, N, Eriksson, J, Vilaseca, A, Muñoz, E & Sterner, O 2008, 'Bioactive alkenylphenols from Piper obliquum.', Bioorganic & Medicinal Chemistry, vol. 16, no. 7, pp. 4120-4126. https://doi.org/10.1016/j.bmc.2008.01.018

APA

Valdivia, C., Marquez, N., Eriksson, J., Vilaseca, A., Muñoz, E., & Sterner, O. (2008). Bioactive alkenylphenols from Piper obliquum. Bioorganic & Medicinal Chemistry, 16(7), 4120-4126. https://doi.org/10.1016/j.bmc.2008.01.018

CBE

MLA

Vancouver

Author

Valdivia, Carola ; Marquez, Nieves ; Eriksson, John ; Vilaseca, Antonio ; Muñoz, Eduardo ; Sterner, Olov. / Bioactive alkenylphenols from Piper obliquum. In: Bioorganic & Medicinal Chemistry. 2008 ; Vol. 16, No. 7. pp. 4120-4126.

RIS

TY - JOUR

T1 - Bioactive alkenylphenols from Piper obliquum.

AU - Valdivia, Carola

AU - Marquez, Nieves

AU - Eriksson, John

AU - Vilaseca, Antonio

AU - Muñoz, Eduardo

AU - Sterner, Olov

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Applied Microbiology (LTH) (011001021), Organic chemistry (S/LTH) (011001240)

PY - 2008

Y1 - 2008

N2 - Various parts of Piper obliquum Ruíz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappaB activity by targeting early events in the TNFalpha-induced NF-kappaB inflammatory pathway, which may explain the effects reported for the traditional use of the plant.

AB - Various parts of Piper obliquum Ruíz & Pavon yielded the new alkenylphenols obliquol A (1) and obliquol B (2), the new 4-chromanone 3 together with the known compounds 4 and 5. A synthesis of obliquol B (2) was developed in order to confirm its structure and to provide sufficient amounts for biological testing. Compounds 1 and 2 have antibacterial activity comparable to that of ampicillin, 2 in addition possesses potent anti-NF-kappaB activity by targeting early events in the TNFalpha-induced NF-kappaB inflammatory pathway, which may explain the effects reported for the traditional use of the plant.

U2 - 10.1016/j.bmc.2008.01.018

DO - 10.1016/j.bmc.2008.01.018

M3 - Article

VL - 16

SP - 4120

EP - 4126

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

SN - 0968-0896

IS - 7

ER -