Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale

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Bibtex

@article{7efeefa6e9004947882d964899c0f21d,
title = "Bioactive compounds isolated from submerged fermentations of the Chilean fungus Stereum rameale",
abstract = "Liquid fermentations of the fungus Stereum rameale (No 2511) yielded extracts with antibacterial -activity. The antibacterial activity reached its peak after 216 h of stirring. Bioassay-guided fractionation methods were employed for the isolation of the bioactive metabolites. Three known compounds were identified: MS-3 (1), vibralactone (2) and vibralactone B (3). The three compounds showed antibacterial activity as a function of their concentration. Minimal bactericidal concentrations (MBC) of compound 1 against Gram-positive bacteria were as follows: Bacillus cereus (50 mu g/mL), Bacillus subtilis (10 mu g/mL) and Staphylococcus aureus (100 mu g/mL). Compounds 2 and 3 were active only against Gram-negative bacteria. The MBC of compound 2 against Escherichia coli was 200 mu g/mL. Compound 3 inhibited significantly the growth of E. coli and Pseudomonas aeruginosa, with MBC values of 50 and 100 mu g/mL, respectively.",
keywords = "antibacterial activity, MIC, MS-3, Stereum rameale, vibralactone",
author = "Pedro Aqueveque and {Leonardo Cespedes}, Carlos and Jose Becerra and Marcelo Davila and Olov Sterner",
year = "2015",
doi = "10.1515/znc-2015-5005",
language = "English",
volume = "70",
pages = "97--102",
journal = "Zeitschrift fur Naturforschung - Section C Journal of Biosciences",
issn = "0939-5075",
publisher = "Verlag der Zeitschrift f{\"u}r Naturforschung",
number = "3-4",

}