Bioactive Pt(II) and Au(I) complexes based on 1,1’-bis(diphenylphosphino)metallocene derivatives

Research output: Contribution to journal › Article

Abstract

New 1,2,1’ substituted bis(diphenylphoshino)ruthenocenes are described and used as ligands in cis-Pt(II) complexes. The new substances were also employed in Au(I) complexes, together with previously described ferrocene-based ligands. Examples of crystal structures are presented for the ligands, as well as for the platinum and gold complexes. The preliminary biological activity covering antitumour, antiviral and antimalarial properties of new gold(I) complexes were very promising.

Details

Authors
  • Haris Bjelosevic
  • Ilia A. Guzei
  • Lara C. Spencer
  • James Darkwa
  • Tina Persson
  • Sofi Elmroth
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Biological Sciences
  • Organic Chemistry

Keywords

  • bioactive, anticancer, metallocenes, gold, platinum, antiviral
Original languageEnglish
JournalHistorielärarnas Förenings Årsskrift
Publication statusUnpublished - 2008
Publication categoryResearch
Peer-reviewedNo

Bibliographic note

The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Biochemistry and Structural Biology (S) (000006142), Organic chemistry (S/LTH) (011001240)

Related research output

BIOACTIVE ORGANOMETALLIC COMPOUNDS
Haris Bjelosevic, 2008, Haris Bjelosevic, Organic Chemistry, Lund University. 85 p.

Research output: Thesis › Doctoral Thesis (compilation)

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