Bioartificial nerve graft for bridging extended nerve defects in rat sciatic nerve based on resorbable guiding filaments

Research output: Contribution to journalArticle


A long defect (15 mm) in rat sciatic nerve was repaired with a bioartificial nerve graft composed of a silicone tube and seven synthetic filaments of five types (polyamide, catgut, polydioxanone, and two types of polyglactin, normal and quickly-absorbed) inserted longitudinally into the tube. In all cases in which filaments were used a regenerating bridge was obtained in the tube after three months in contrast to empty silicone tubes, in which no structure was observed. There was a 6% ~ 46% recovery of isometric muscle contractility of the anterior tibial and gastrocnemius muscles with positive pinch reflex test in most cases. Myelinated axons were seen in the regenerating tissue between the filaments but not directly in contact with them, and there were varying numbers of macrophages close to the filaments. Silicone tubes with filaments, regardless of type of filament, induced nerve tissue to regenerate and resulted in functional recovery through a 15 mm nerve gap not achieved with empty tubes. Nerve promoting factors may be applied to the filaments and the model is a valuable tool for further development of artificial nerve grafts.


External organisations
  • Keio University
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Surgery


  • Axonal growth, Biomaterial, Nerve graft, Nerve regeneration, Resorbable filaments, Silicone chamber
Original languageEnglish
Pages (from-to)101-108
Number of pages8
JournalScandinavian Journal of Plastic and Reconstructive Surgery and Hand Surgery
Issue number2
Publication statusPublished - 2000 Aug 10
Publication categoryResearch