Biochemical and functional evidence for nerve sprouting in the decentralized, hypertrophied rat urinary bladder

Research output: Contribution to journalArticle


The preganglionic nerves of the rat urinary bladder were cut. The decentralized bladders gained markedly in weight. Both one and four weeks post-operatively, transmural nerve stimulation evoked contractile responses of the muscle strips of the decentralized bladders, that were of the same magnitude as those of the control bladders. However, four weeks post-operatively, the atropine resistant fraction of the response was decreased; consequently, the atropine sensitive (cholinergic) fraction was increased. The activity of the acetylcholine synthesizing enzyme, choline acetyltransferase, was increased at the late time of observation. The present biochemical and functional findings may suggest outgrowth of branches from the decentralized post-ganglionic cholinergic nerves.


  • J Ekstrom
  • Lars Malmberg
  • A Wallin
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Urology and Nephrology
Original languageEnglish
Pages (from-to)86-89
JournalPharmacology and Toxicology
Issue number2
Publication statusPublished - 1987
Publication categoryResearch