Biochemical and functional evidence for nerve sprouting in the decentralized, hypertrophied rat urinary bladder

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Biochemical and functional evidence for nerve sprouting in the decentralized, hypertrophied rat urinary bladder. / Ekstrom, J; Malmberg, Lars; Wallin, A.

In: Pharmacology and Toxicology, Vol. 60, No. 2, 1987, p. 86-89.

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TY - JOUR

T1 - Biochemical and functional evidence for nerve sprouting in the decentralized, hypertrophied rat urinary bladder

AU - Ekstrom, J

AU - Malmberg, Lars

AU - Wallin, A

PY - 1987

Y1 - 1987

N2 - The preganglionic nerves of the rat urinary bladder were cut. The decentralized bladders gained markedly in weight. Both one and four weeks post-operatively, transmural nerve stimulation evoked contractile responses of the muscle strips of the decentralized bladders, that were of the same magnitude as those of the control bladders. However, four weeks post-operatively, the atropine resistant fraction of the response was decreased; consequently, the atropine sensitive (cholinergic) fraction was increased. The activity of the acetylcholine synthesizing enzyme, choline acetyltransferase, was increased at the late time of observation. The present biochemical and functional findings may suggest outgrowth of branches from the decentralized post-ganglionic cholinergic nerves.

AB - The preganglionic nerves of the rat urinary bladder were cut. The decentralized bladders gained markedly in weight. Both one and four weeks post-operatively, transmural nerve stimulation evoked contractile responses of the muscle strips of the decentralized bladders, that were of the same magnitude as those of the control bladders. However, four weeks post-operatively, the atropine resistant fraction of the response was decreased; consequently, the atropine sensitive (cholinergic) fraction was increased. The activity of the acetylcholine synthesizing enzyme, choline acetyltransferase, was increased at the late time of observation. The present biochemical and functional findings may suggest outgrowth of branches from the decentralized post-ganglionic cholinergic nerves.

M3 - Article

VL - 60

SP - 86

EP - 89

JO - Basic and Clinical Pharmacology and Toxicology

JF - Basic and Clinical Pharmacology and Toxicology

SN - 1742-7843

IS - 2

ER -