Biofuel cell based on microscale nanostructured electrodes with inductive coupling to rat brain neurons.

Research output: Contribution to journalArticle

Abstract

Miniature, self-contained biodevices powered by biofuel cells may enable a new generation of implantable, wireless, minimally invasive neural interfaces for neurophysiological in vivo studies and for clinical applications. Here we report on the fabrication of a direct electron transfer based glucose/oxygen enzymatic fuel cell (EFC) from genuinely three-dimensional (3D) nanostructured microscale gold electrodes, modified with suitable biocatalysts. We show that the process underlying the simple fabrication method of 3D nanostructured electrodes is based on an electrochemically driven transformation of physically deposited gold nanoparticles. We experimentally demonstrate that mediator-, cofactor-, and membrane-less EFCs do operate in cerebrospinal fluid and in the brain of a rat, producing amounts of electrical power sufficient to drive a self-contained biodevice, viz. 7 μW cm(-2) in vitro and 2 μW cm(-2) in vivo at an operating voltage of 0.4 V. Last but not least, we also demonstrate an inductive coupling between 3D nanobioelectrodes and living neurons.

Details

Authors
  • Viktor Andoralov
  • Magnus Falk
  • Dmitry Suyatin
  • Marcus Granmo
  • Javier Sotres
  • Roland Ludwig
  • Vladimir O Popov
  • Jens Schouenborg
  • Zoltan Blum
  • Sergey Shleev
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences
Original languageEnglish
Article number3270
JournalScientific Reports
Volume3
Issue numberNov 20
Publication statusPublished - 2013
Publication categoryResearch
Peer-reviewedYes

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