Biological dermal templates with native collagen scaffolds provide guiding ridges for invading cells and may promote structured dermal wound healing

Research output: Contribution to journalArticle

Abstract

Dermal substitutes are of major importance in treating full thickness skin defects. They come in a variety of materials manufactured into various forms, such as films, hydrocolloids, hydrogels, sponges, membranes, and electrospun micro- and nanofibers. Bioactive dermal substitutes act in wound healing either by delivery of bioactive compounds or by being constructed from materials having endogenous activity. The healing success rate is highly determined by cellular and physiological processes at the host-biomaterial interface during crucial wound healing steps. Hence, it is important to design appropriate wound treatment strategies with the ability to work actively with tissues and cells to enhance healing. Therefore, in this study, we investigated biological dermal templates and their potential to stimulate natural cell adherence, guidance, and morphology. The most pronounced effect was observed in biomaterials with the highest content of native collagen networks. Cell attachment and proliferation were significantly enhanced on native collagen scaffolds. Cell morphology was more asymmetrical on such scaffolds, resembling native in vivo structures. Importantly, considerably lower expression of myofibroblast phenotype was observed on native collagen scaffolds. Our data suggest that this treatment strategy might be beneficial for the wound environment, with the potential to promote improved tissue regeneration and reduce abnormal scar formation.

Details

Authors
  • Veronika Dill
  • Matthias Mörgelin
Organisations
External organisations
  • Colzyx AB
  • Lund University
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Materials

Keywords

  • bioactive dermal template, cell adherence, cell proliferation, native collagen scaffold, structured healing
Original languageEnglish
Pages (from-to)618-630
Number of pages13
JournalInternational Wound Journal
Volume17
Issue number3
Early online date2020
Publication statusPublished - 2020 Jun
Publication categoryResearch
Peer-reviewedYes