Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans

Research output: Contribution to journalArticle

Standard

Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans. / Blessing, Esther M.; Reus, Victor I; Mellon, Synthia H; Wolkowitz, Owen M; Flory, Janine D; Bierer, Linda M; Lindqvist, Daniel; Dhabhar, Firdaus S; Li, Meng; Qian, Meng; Abu-Amara, Duna; Galatzer-Levy, Isaac; Yehuda, Rachel; Marmar, Charles R.

In: Psychoneuroendocrinology, Vol. 82, 01.08.2017, p. 91-97.

Research output: Contribution to journalArticle

Harvard

Blessing, EM, Reus, VI, Mellon, SH, Wolkowitz, OM, Flory, JD, Bierer, LM, Lindqvist, D, Dhabhar, FS, Li, M, Qian, M, Abu-Amara, D, Galatzer-Levy, I, Yehuda, R & Marmar, CR 2017, 'Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans', Psychoneuroendocrinology, vol. 82, pp. 91-97. https://doi.org/10.1016/j.psyneuen.2017.04.016

APA

Blessing, E. M., Reus, V. I., Mellon, S. H., Wolkowitz, O. M., Flory, J. D., Bierer, L. M., ... Marmar, C. R. (2017). Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans. Psychoneuroendocrinology, 82, 91-97. https://doi.org/10.1016/j.psyneuen.2017.04.016

CBE

Blessing EM, Reus VI, Mellon SH, Wolkowitz OM, Flory JD, Bierer LM, Lindqvist D, Dhabhar FS, Li M, Qian M, Abu-Amara D, Galatzer-Levy I, Yehuda R, Marmar CR. 2017. Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans. Psychoneuroendocrinology. 82:91-97. https://doi.org/10.1016/j.psyneuen.2017.04.016

MLA

Vancouver

Author

Blessing, Esther M. ; Reus, Victor I ; Mellon, Synthia H ; Wolkowitz, Owen M ; Flory, Janine D ; Bierer, Linda M ; Lindqvist, Daniel ; Dhabhar, Firdaus S ; Li, Meng ; Qian, Meng ; Abu-Amara, Duna ; Galatzer-Levy, Isaac ; Yehuda, Rachel ; Marmar, Charles R. / Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans. In: Psychoneuroendocrinology. 2017 ; Vol. 82. pp. 91-97.

RIS

TY - JOUR

T1 - Biological predictors of insulin resistance associated with posttraumatic stress disorder in young military veterans

AU - Blessing, Esther M.

AU - Reus, Victor I

AU - Mellon, Synthia H

AU - Wolkowitz, Owen M

AU - Flory, Janine D

AU - Bierer, Linda M

AU - Lindqvist, Daniel

AU - Dhabhar, Firdaus S

AU - Li, Meng

AU - Qian, Meng

AU - Abu-Amara, Duna

AU - Galatzer-Levy, Isaac

AU - Yehuda, Rachel

AU - Marmar, Charles R

PY - 2017/8/1

Y1 - 2017/8/1

N2 - Posttraumatic stress disorder (PTSD) is associated with increased risk for Type 2 diabetes and cardiovascular disease (cardiometabolic disease), warranting research into targeted prevention strategies. In the present case–control study of 160 young (mean age 32.7 years) male military veterans, we aimed to assess whether PTSD status predicted increased markers of cardiometabolic risk in otherwise healthy individuals, and further, to explore biological pathways between PTSD and these increased markers of cardiometabolic risk. Toward these aims, we compared measures of cardiometabolic risk, namely insulin resistance (IR) (HOMA-IR), metabolic syndrome (MetS) and prediabetes, between 80 PTSD cases and 80 controls without PTSD. We then determined whether PTSD-associated increases in HOMA-IR were correlated with select biological variables from pathways previously hypothesized to link PTSD with cardiometabolic risk, including systemic inflammation (increased C-reactive protein, interleukin-6, and tumor necrosis factor α), sympathetic over-activity (increased resting heart rate), and neuroendocrine dysregulation (increased plasma cortisol or serum brain-derived neurotrophic factor (BDNF)). We found PTSD diagnosis was associated with substantially higher HOMA-IR (cases 4.3 ± 4.3 vs controls 2.4 ± 2.0; p < 0.001), and a higher frequency of MetS (cases 21.3% vs controls 2.5%; p < 0.001), but not prediabetes (cases 20.0% vs controls 18.8%; p > 0.05). Cases also had increased pro-inflammatory cytokines (p < 0.01), heart rate (p < 0.001), and BDNF (p < 0.001), which together predicted increased HOMA-IR (adjusted R2 = 0.68, p < 0.001). Results show PTSD diagnosis in young male military veterans without cardiometabolic disease is associated with increased IR, predicted by biological alterations previously hypothesized to link PTSD to increased cardiometabolic risk. Findings support further research into early, targeted prevention of cardiometabolic disease in individuals with PTSD.

AB - Posttraumatic stress disorder (PTSD) is associated with increased risk for Type 2 diabetes and cardiovascular disease (cardiometabolic disease), warranting research into targeted prevention strategies. In the present case–control study of 160 young (mean age 32.7 years) male military veterans, we aimed to assess whether PTSD status predicted increased markers of cardiometabolic risk in otherwise healthy individuals, and further, to explore biological pathways between PTSD and these increased markers of cardiometabolic risk. Toward these aims, we compared measures of cardiometabolic risk, namely insulin resistance (IR) (HOMA-IR), metabolic syndrome (MetS) and prediabetes, between 80 PTSD cases and 80 controls without PTSD. We then determined whether PTSD-associated increases in HOMA-IR were correlated with select biological variables from pathways previously hypothesized to link PTSD with cardiometabolic risk, including systemic inflammation (increased C-reactive protein, interleukin-6, and tumor necrosis factor α), sympathetic over-activity (increased resting heart rate), and neuroendocrine dysregulation (increased plasma cortisol or serum brain-derived neurotrophic factor (BDNF)). We found PTSD diagnosis was associated with substantially higher HOMA-IR (cases 4.3 ± 4.3 vs controls 2.4 ± 2.0; p < 0.001), and a higher frequency of MetS (cases 21.3% vs controls 2.5%; p < 0.001), but not prediabetes (cases 20.0% vs controls 18.8%; p > 0.05). Cases also had increased pro-inflammatory cytokines (p < 0.01), heart rate (p < 0.001), and BDNF (p < 0.001), which together predicted increased HOMA-IR (adjusted R2 = 0.68, p < 0.001). Results show PTSD diagnosis in young male military veterans without cardiometabolic disease is associated with increased IR, predicted by biological alterations previously hypothesized to link PTSD to increased cardiometabolic risk. Findings support further research into early, targeted prevention of cardiometabolic disease in individuals with PTSD.

KW - Brain derived neurotrophic factor

KW - Inflammation

KW - Insulin resistance

KW - Prediabetes

KW - PTSD

KW - Sympathetic

UR - http://www.scopus.com/inward/record.url?scp=85019207121&partnerID=8YFLogxK

U2 - 10.1016/j.psyneuen.2017.04.016

DO - 10.1016/j.psyneuen.2017.04.016

M3 - Article

VL - 82

SP - 91

EP - 97

JO - Psychoneuroendocrinology

T2 - Psychoneuroendocrinology

JF - Psychoneuroendocrinology

SN - 1873-3360

ER -