Biomarkers for diagnosis and prediction of therapy responses in allergic diseases and asthma

Research output: Contribution to journalReview article


Modern health care requires a proactive and individualized response to diseases, combining precision diagnosis and personalized treatment. Accordingly, the approach to patients with allergic diseases encompasses novel developments in the area of personalized medicine, disease phenotyping and endotyping, and the development and application of reliable biomarkers. A detailed clinical history and physical examination followed by the detection of IgE immunoreactivity against specific allergens still represents the state of the art. However, nowadays, further emphasis focuses on the optimization of diagnostic and therapeutic standards and a large number of studies have been investigating the biomarkers of allergic diseases, including asthma, atopic dermatitis, allergic rhinitis, food allergy, urticaria and anaphylaxis. Various biomarkers have been developed by omics technologies, some of which lead to a better classification of distinct phenotypes or endotypes. The introduction of biologicals to clinical practice increases the need for biomarkers for patient selection, prediction of outcomes and monitoring, to allow for an adequate choice of the duration of these costly and long-lasting therapies. Escalating healthcare costs together with questions about the efficacy of the current management of allergic diseases require further development of a biomarker-driven approach. Here, we review biomarkers in diagnosis and treatment of asthma, atopic dermatitis, allergic rhinitis, viral infections, chronic rhinosinusitis, food allergy, drug hypersensitivity and allergen immunotherapy with a special emphasis on specific IgE, the microbiome and the epithelial barrier. In addition, EAACI guidelines on biologicals are discussed within the perspective of biomarkers.


  • Heimo Breiteneder
  • Ya Qi Peng
  • Ioana Agache
  • Zuzana Diamant
  • Thomas Eiwegger
  • Wytske J. Fokkens
  • Claudia Traidl-Hoffmann
  • Kari Nadeau
  • Robyn E. O'Hehir
  • Liam O'Mahony
  • Oliver Pfaar
  • Maria J. Torres
  • De Yun Wang
  • Luo Zhang
  • Cezmi A. Akdis
External organisations
  • Transylvania University Brasov
  • Skåne University Hospital
  • Charles University in Prague
  • University Medical Center Groningen
  • Hospital for Sick Children, Toronto
  • University of Toronto
  • Academic Medical Center of University of Amsterdam (AMC)
  • Stanford University
  • University Hospital Giessen and Marburg
  • Hospital Regional de Málaga
  • National University of Singapore
  • Beijing Tongren Hospital
  • Medical University of Vienna
  • University of Zurich
  • Christine Kühne Center for Allergy Research and Education (CK-CARE)
  • Technical University of Munich
  • Helmholtz Zentrum München
  • Monash University
  • Alfred Health
  • University College Cork
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Respiratory Medicine and Allergy


  • allergen immunotherapy, allergic rhinitis, asthma phenotypes and endotypes, biomarkers, food allergy
Original languageEnglish
Pages (from-to)3039-3068
Number of pages30
JournalAllergy: European Journal of Allergy and Clinical Immunology
Issue number12
Early online date2020 Sep 7
Publication statusPublished - 2020 Dec
Publication categoryResearch