Biophysics of viral infectivity: matching genome length with capsid size.
Research output: Contribution to journal › Article
In this review, we discuss recent advances in biophysical virology, presenting experimental and theoretical studies on the physical properties of viruses. We focus on the double-stranded (ds) DNA bacteriophages as model systems for all of the dsDNA viruses both prokaryotic and eukaryotic. Recent studies demonstrate that the DNA packaged into a viral capsid is highly pressurized, which provides a force for the first step of passive injection of viral DNA into a bacterial cell. Moreover, specific studies on capsid strength show a strong correlation between genome length, and capsid size and robustness. The implications of these newly appreciated physical properties of a viral particle with respect to the infection process are discussed.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Quarterly Reviews of Biophysics|
|Publication status||Published - 2007|