Biophysics of viral infectivity: matching genome length with capsid size.

Research output: Contribution to journalArticle


title = "Biophysics of viral infectivity: matching genome length with capsid size.",
abstract = "In this review, we discuss recent advances in biophysical virology, presenting experimental and theoretical studies on the physical properties of viruses. We focus on the double-stranded (ds) DNA bacteriophages as model systems for all of the dsDNA viruses both prokaryotic and eukaryotic. Recent studies demonstrate that the DNA packaged into a viral capsid is highly pressurized, which provides a force for the first step of passive injection of viral DNA into a bacterial cell. Moreover, specific studies on capsid strength show a strong correlation between genome length, and capsid size and robustness. The implications of these newly appreciated physical properties of a viral particle with respect to the infection process are discussed.",
author = "Elmar Nurmemmedov and Martin Castelnovo and Catalano, {Carlos Enrique} and Alex Evilevitch",
year = "2007",
doi = "10.1017/S0033583508004666",
language = "English",
volume = "40",
pages = "327--356",
journal = "Quarterly Reviews of Biophysics",
issn = "1469-8994",
publisher = "Cambridge University Press",
number = "4",