Biophysics of viral infectivity: matching genome length with capsid size.

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Biophysics of viral infectivity: matching genome length with capsid size. / Nurmemmedov, Elmar; Castelnovo, Martin; Catalano, Carlos Enrique; Evilevitch, Alex.

In: Quarterly Reviews of Biophysics, Vol. 40, No. 4, 2007, p. 327-356.

Research output: Contribution to journalArticle

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Nurmemmedov, Elmar ; Castelnovo, Martin ; Catalano, Carlos Enrique ; Evilevitch, Alex. / Biophysics of viral infectivity: matching genome length with capsid size. In: Quarterly Reviews of Biophysics. 2007 ; Vol. 40, No. 4. pp. 327-356.

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TY - JOUR

T1 - Biophysics of viral infectivity: matching genome length with capsid size.

AU - Nurmemmedov, Elmar

AU - Castelnovo, Martin

AU - Catalano, Carlos Enrique

AU - Evilevitch, Alex

PY - 2007

Y1 - 2007

N2 - In this review, we discuss recent advances in biophysical virology, presenting experimental and theoretical studies on the physical properties of viruses. We focus on the double-stranded (ds) DNA bacteriophages as model systems for all of the dsDNA viruses both prokaryotic and eukaryotic. Recent studies demonstrate that the DNA packaged into a viral capsid is highly pressurized, which provides a force for the first step of passive injection of viral DNA into a bacterial cell. Moreover, specific studies on capsid strength show a strong correlation between genome length, and capsid size and robustness. The implications of these newly appreciated physical properties of a viral particle with respect to the infection process are discussed.

AB - In this review, we discuss recent advances in biophysical virology, presenting experimental and theoretical studies on the physical properties of viruses. We focus on the double-stranded (ds) DNA bacteriophages as model systems for all of the dsDNA viruses both prokaryotic and eukaryotic. Recent studies demonstrate that the DNA packaged into a viral capsid is highly pressurized, which provides a force for the first step of passive injection of viral DNA into a bacterial cell. Moreover, specific studies on capsid strength show a strong correlation between genome length, and capsid size and robustness. The implications of these newly appreciated physical properties of a viral particle with respect to the infection process are discussed.

U2 - 10.1017/S0033583508004666

DO - 10.1017/S0033583508004666

M3 - Article

VL - 40

SP - 327

EP - 356

JO - Quarterly Reviews of Biophysics

JF - Quarterly Reviews of Biophysics

SN - 1469-8994

IS - 4

ER -