Bioresorbable and nonresorbable macroporous thermosensitive hydrogels prepared by cryopolymerization. Role of the cross-linking agent

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Bioresorbable and nonresorbable macroporous thermosensitive hydrogels prepared by cryopolymerization. Role of the cross-linking agent. / Perez, Paloma; Plieva, Fatima; Gallardo, Alberto; Roman, Julio San; Aguilar, Maria Rosa; Morfin, Isabelle; Ehrburger-Dolle, Frangoise; Bley, Francoise; Mikhalovsky, Sergey; Galaev, Igor; Mattiasson, Bo.

In: Biomacromolecules, Vol. 9, No. 1, 2008, p. 66-74.

Research output: Contribution to journalArticle

Harvard

Perez, P, Plieva, F, Gallardo, A, Roman, JS, Aguilar, MR, Morfin, I, Ehrburger-Dolle, F, Bley, F, Mikhalovsky, S, Galaev, I & Mattiasson, B 2008, 'Bioresorbable and nonresorbable macroporous thermosensitive hydrogels prepared by cryopolymerization. Role of the cross-linking agent', Biomacromolecules, vol. 9, no. 1, pp. 66-74. https://doi.org/10.1021/bm7007668

APA

CBE

Perez P, Plieva F, Gallardo A, Roman JS, Aguilar MR, Morfin I, Ehrburger-Dolle F, Bley F, Mikhalovsky S, Galaev I, Mattiasson B. 2008. Bioresorbable and nonresorbable macroporous thermosensitive hydrogels prepared by cryopolymerization. Role of the cross-linking agent. Biomacromolecules. 9(1):66-74. https://doi.org/10.1021/bm7007668

MLA

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Author

Perez, Paloma ; Plieva, Fatima ; Gallardo, Alberto ; Roman, Julio San ; Aguilar, Maria Rosa ; Morfin, Isabelle ; Ehrburger-Dolle, Frangoise ; Bley, Francoise ; Mikhalovsky, Sergey ; Galaev, Igor ; Mattiasson, Bo. / Bioresorbable and nonresorbable macroporous thermosensitive hydrogels prepared by cryopolymerization. Role of the cross-linking agent. In: Biomacromolecules. 2008 ; Vol. 9, No. 1. pp. 66-74.

RIS

TY - JOUR

T1 - Bioresorbable and nonresorbable macroporous thermosensitive hydrogels prepared by cryopolymerization. Role of the cross-linking agent

AU - Perez, Paloma

AU - Plieva, Fatima

AU - Gallardo, Alberto

AU - Roman, Julio San

AU - Aguilar, Maria Rosa

AU - Morfin, Isabelle

AU - Ehrburger-Dolle, Frangoise

AU - Bley, Francoise

AU - Mikhalovsky, Sergey

AU - Galaev, Igor

AU - Mattiasson, Bo

PY - 2008

Y1 - 2008

N2 - Macroporous poly(N-isopropylacrylamide) (pNIPA) gels (so-called cryogels), cross-linked with different bisacryliccompounds, N,N'-methylenebisacrylamide (MBAAm) and dimethacrylate-tyrosine-lysine-tyrosine (DMTLT), were prepared through free-radical polymerization at subzero temperature in dioxane/water media. DMTLT is a hydrolytically degradable cross-linker with relatively hydrophobic character. The effects of different synthesis conditions, namely the concentration of monomers, the cross-linker, and the initiator in the reaction mixture, on the structure of the pNIPA-cryogels have been studied. The equilibrium swelling ratio of the DMTLT crosslinked pNIPA cryogels at temperatures below lower critical solution temperature (LCST) of pNIPA, was over ten times higher than that of the gels synthesized at room temperature from the same feed composition. The MBAAm cross-linked pNIPA cryogels synthesized in water exhibited the highest equilibrium swelling and the fastest response. The critical transition temperature, T-c, was lower (T-c approximate to 31 degrees C) for pNIPA-cryogels synthesized in dioxane/water media or cross-linked with DMTLT as compared to MBAAm cross-linked pNIPA cryogels synthesized in water (T-c approximate to 33 degrees C). Scanning electron microscopy (SEM) revealed different porous structure and pore surface morphology depending on the cross-linker (MBAAm or DMTLT) and the solvent (water or dioxane/water) used. Gels and cryogels were also characterized by SAXS, showing that the nanostructure of the samples is related to swelling.

AB - Macroporous poly(N-isopropylacrylamide) (pNIPA) gels (so-called cryogels), cross-linked with different bisacryliccompounds, N,N'-methylenebisacrylamide (MBAAm) and dimethacrylate-tyrosine-lysine-tyrosine (DMTLT), were prepared through free-radical polymerization at subzero temperature in dioxane/water media. DMTLT is a hydrolytically degradable cross-linker with relatively hydrophobic character. The effects of different synthesis conditions, namely the concentration of monomers, the cross-linker, and the initiator in the reaction mixture, on the structure of the pNIPA-cryogels have been studied. The equilibrium swelling ratio of the DMTLT crosslinked pNIPA cryogels at temperatures below lower critical solution temperature (LCST) of pNIPA, was over ten times higher than that of the gels synthesized at room temperature from the same feed composition. The MBAAm cross-linked pNIPA cryogels synthesized in water exhibited the highest equilibrium swelling and the fastest response. The critical transition temperature, T-c, was lower (T-c approximate to 31 degrees C) for pNIPA-cryogels synthesized in dioxane/water media or cross-linked with DMTLT as compared to MBAAm cross-linked pNIPA cryogels synthesized in water (T-c approximate to 33 degrees C). Scanning electron microscopy (SEM) revealed different porous structure and pore surface morphology depending on the cross-linker (MBAAm or DMTLT) and the solvent (water or dioxane/water) used. Gels and cryogels were also characterized by SAXS, showing that the nanostructure of the samples is related to swelling.

U2 - 10.1021/bm7007668

DO - 10.1021/bm7007668

M3 - Article

VL - 9

SP - 66

EP - 74

JO - Biomacromolecules

T2 - Biomacromolecules

JF - Biomacromolecules

SN - 1526-4602

IS - 1

ER -