Bivalent polyether ionophores: Synthesis and biological evaluation of C2-symmetric salinomycin dimers

Research output: Contribution to journalArticle

Abstract

Efficient methods for the synthesis of C2-symmetric dimers of salinomycin joined at either the C1 or C20 positions are reported. Similarly to the native structure, the C20-O-terephthalate dimer displayed activity in the low μM range against a series of cancer cell lines, while dimers joined at the C1 position were essentially inactive.

Details

Authors
Organisations
External organisations
  • Adam Mickiewicz University in Poznań
  • Polish Academy of Sciences
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Biochemistry and Molecular Biology

Keywords

  • Anti-proliferative activity, Glaser-type coupling reaction, Ionophore antibiotics, Multivalent structures, SRB assay
Original languageEnglish
Pages (from-to)2396-2399
Number of pages4
JournalTetrahedron Letters
Volume58
Issue number24
Publication statusPublished - 2017
Publication categoryResearch
Peer-reviewedYes