Blood pressure and LDL-cholesterol targets for prevention of recurrent strokes and cognitive decline in the hypertensive patient: design of the European Society of Hypertension-Chinese Hypertension League Stroke in Hypertension Optimal Treatment randomized trial.

Research output: Contribution to journalArticle

Abstract

The SBP values to be achieved by antihypertensive therapy in order to maximize reduction of cardiovascular outcomes are unknown; neither is it clear whether in patients with a previous cardiovascular event, the optimal values are lower than in the low-to-moderate risk hypertensive patients, or a more cautious blood pressure (BP) reduction should be obtained. Because of the uncertainty whether 'the lower the better' or the 'J-curve' hypothesis is correct, the European Society of Hypertension and the Chinese Hypertension League have promoted a randomized trial comparing antihypertensive treatment strategies aiming at three different SBP targets in hypertensive patients with a recent stroke or transient ischaemic attack. As the optimal level of low-density lipoprotein cholesterol (LDL-C) level is also unknown in these patients, LDL-C-lowering has been included in the design.

Details

Authors
  • Alberto Zanchetti
  • Lisheng Liu
  • Giuseppe Mancia
  • Gianfranco Parati
  • Guido Grassi
  • Marco Stramba-Badiale
  • Vincenzo Silani
  • Grzegorz Bilo
  • Giovanni Corrao
  • Antonella Zambon
  • Lorenza Scotti
  • Xinhua Zhang
  • HayYan Wang
  • Yuqing Zhang
  • Xuezhong Zhang
  • Ting Rui Guan
  • Eivind Berge
  • Josep Redon
  • Krzysztof Narkiewicz
  • Anna Dominiczak
  • Margus Viigimaa
  • Stéphane Laurent
  • Enrico Agabiti-Rosei
  • Zhaosu Wu
  • Dingliang Zhu
  • José Luis Rodicio
  • Luis Miguel Ruilope
  • Nieves Martell-Claros
  • Fernando Pinto
  • Roland E Schmieder
  • Michel Burnier
  • Maciej Banach
  • Renata Cifkova
  • Csaba Farsang
  • Alexandra Konradi
  • Irina Lazareva
  • Yuriy Sirenko
  • Maria Dorobantu
  • Arman Postadzhiyan
  • Rok Accetto
  • Bojan Jelakovic
  • Dragan Lovic
  • Athanasios J Manolis
  • Philippos Stylianou
  • Serap Erdine
  • Dror Dicker
  • Gangzhi Wei
  • Chengbin Xu
  • Hengge Xie
  • Antonio Coca
  • John O'Brien
  • Gary Ford
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
Original languageEnglish
Pages (from-to)1888-1897
JournalJournal of Hypertension
Volume32
Issue number9
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes