Blood pressure and low-density lipoprotein-cholesterol lowering for prevention of strokes and cognitive decline: a review of available trial evidence.

Research output: Contribution to journalReview article


It is well established by a large number of randomized controlled trials that lowering blood pressure (BP) and low-density lipoprotein cholesterol (LDL-C) by drugs are powerful means to reduce stroke incidence, but the optimal BP and LDL-C levels to be achieved are largely uncertain. Concerning BP targets, two hypotheses are being confronted: first, the lower the BP, the better the treatment outcome, and second, the hypothesis that too low BP values are accompanied by a lower benefit and even higher risk. It is also unknown whether BP lowering and LDL-C lowering have additive beneficial effects for the primary and secondary prevention of stroke, and whether these treatments can prevent cognitive decline after stroke.


  • Alberto Zanchetti
  • Lisheng Liu
  • Giuseppe Mancia
  • Gianfranco Parati
  • Guido Grassi
  • Marco Stramba-Badiale
  • Vincenzo Silani
  • Grzegorz Bilo
  • Giovanni Corrao
  • Antonella Zambon
  • Lorenza Scotti
  • Xinhua Zhang
  • HayYan Wang
  • Yuqing Zhang
  • Xuezhong Zhang
  • Ting Rui Guan
  • Eivind Berge
  • Josep Redon
  • Krzysztof Narkiewicz
  • Anna Dominiczak
  • Margus Viigimaa
  • Stéphane Laurent
  • Enrico Agabiti-Rosei
  • Zhaosu Wu
  • Dingliang Zhu
  • José Luis Rodicio
  • Luis Miguel Ruilope
  • Nieves Martell-Claros
  • Fernando Pinto
  • Roland E Schmieder
  • Michel Burnier
  • Maciej Banach
  • Renata Cifkova
  • Csaba Farsang
  • Alexandra Konradi
  • Irina Lazareva
  • Yuriy Sirenko
  • Maria Dorobantu
  • Arman Postadzhiyan
  • Rok Accetto
  • Bojan Jelakovic
  • Dragan Lovic
  • Athanasios J Manolis
  • Philippos Stylianou
  • Serap Erdine
  • Dror Dicker
  • Gangzhi Wei
  • Chengbin Xu
  • Hengge Xie
  • Antonio Coca
  • John O'Brien
  • Gary Ford
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems
Original languageEnglish
Pages (from-to)1741-1750
JournalJournal of Hypertension
Issue number9
Publication statusPublished - 2014
Publication categoryResearch