Brain natriuretic peptide is a potent vasodilator in aged human microcirculation and shows a blunted response in heart failure patients.

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Abstract

Brain natriuretic peptide (BNP) is normally present in low levels in the circulation, but it is elevated in parallel with the degree of congestion in heart failure subjects (CHF). BNP has natriuretic effects and is a potent vasodilator. It is suggested that BNP could be a therapeutic alternative in CHF. However, we postulated that the high levels of circulating BNP in CHF may downregulate the response of microvascular natriuretic receptors. This was tested by comparing 15 CHF patients (BNP > 3000 ng/L) with 10 matched, healthy controls.

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  • Other Clinical Medicine
Original languageEnglish
Pages (from-to)50-56
JournalJournal of geriatric cardiology : JGC
Volume11
Issue number1
Publication statusPublished - 2014
Publication categoryResearch
Peer-reviewedYes

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