Brain stem audiometry may supply markers for diagnostic and therapeutic control in psychiatry

Research output: Contribution to journalArticle

Abstract

The purpose of the present study is to try an alternative way of analyzing the ABR (Auditory Brainstem Response). The stimuli were complex sounds (c-ABR) as used in earlier studies. It was further aimed at corroborating earlier findings that this method can discriminate several neuropsychiatric states. Forty healthy control subjects, 26 subjects with the diagnosis schizophrenia (Sz) and 33 with ADHD (Attention deficit hyperactivity disorder) were recruited for the study. The ABRs were recorded. The analysis was based on calculation of areas of significantly group different time spans in the waves. Both latency and amplitude were thereby influential. The spans of differences were quantified for each subject in relation to the total area of the curve which made comparisons balanced. The results showed highly significant differences between the study groups. The results are important for future work on identifying markers for neuropsychiatric clinical use. To reach that goal calls for more extensive studies than this preliminary one.

Details

Authors
  • Sören Nielzén
  • Jens Holmberg
  • Mia Sköld
  • Sara Nehlstedt
Organisations
External organisations
  • SensoDetect AB
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Psychiatry

Keywords

  • ADHD, Auditory brainstem response, Biomarker, Brainstem, Schizophrenia
Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalNeuroscience Letters
Volume632
Early online date2016 Oct 6
Publication statusPublished - 2016
Publication categoryResearch
Peer-reviewedYes

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