Breast and ovarian cancer risks to carriers of the BRCA1 5382insC and 185delAG and BRCA2 6174delT mutations: a combined analysis of 22 population based studies

Research output: Contribution to journalArticle


A recent report estimated the breast cancer risks in carriers of the three Ashkenazi founder mutations to be higher than previously published estimates derived from population based studies. In an attempt to confirm this, the breast and ovarian cancer risks associated with the three Ashkenazi founder mutations were estimated using families included in a previous meta-analysis of populatrion based studies. The estimated breast cancer risks for each of the founder BRCA1 and BRCA2 mutations were similar to the corresponding estimates based on all BRCA1 or BRCA2 mutations in the meta-analysis. These estimates appear to be consistent with the observed prevalence of the mutations in the Ashkenazi Jewish population.


  • A C Antoniou
  • P D P Pharoah
  • S Narod
  • H A Risch
  • J E Eyfjord
  • J L Hopper
  • O Johannsson
  • B Pasini
  • P Radice
  • S Manoukian
  • D M Eccles
  • N Tang
  • E Olah
  • H Anton-Culver
  • E Warner
  • J Lubinski
  • J Gronwald
  • B Gorski
  • H Tulinius
  • S Thorlacius
  • H Eerola
  • H Nevanlinna
  • K Syrjakoski
  • O P Kallioniemi
  • D Thompson
  • C Evans
  • J Peto
  • F Lalloo
  • D G Evans
  • D F Easton
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Medical Genetics
Original languageEnglish
Pages (from-to)602-603
JournalJournal of Medical Genetics
Issue number7
Publication statusPublished - 2005
Publication categoryResearch