Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis
Research output: Contribution to journal › Article
Th2 cytokines like interleukin-4, -5, and -13 are regarded as important drivers of the immunopathology underlying allergic rhinitis (AR) and asthma. The present study explores the capacity of pentosan polysulfate sodium (PPS), a semi-synthetic heparin-like macromolecular carbohydrate, to bind Th2 cytokines and exert biological neutralization in vitro, as well as anti-inflammatory actions in vivo.
|Research areas and keywords||
Subject classification (UKÄ) – MANDATORY
|Journal||Immunity, Inflammation and Disease|
|Early online date||2017 May 12|
|Publication status||Published - 2017|