Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis

Research output: Contribution to journalArticle

Abstract

Th2 cytokines like interleukin-4, -5, and -13 are regarded as important drivers of the immunopathology underlying allergic rhinitis (AR) and asthma. The present study explores the capacity of pentosan polysulfate sodium (PPS), a semi-synthetic heparin-like macromolecular carbohydrate, to bind Th2 cytokines and exert biological neutralization in vitro, as well as anti-inflammatory actions in vivo.

Details

Authors
Organisations
External organisations
  • Medetect AB
  • Lund University
  • Paradigm Biopharmaceuticals Ltd.
  • Shanghai Institute of Clinical Bioinformatics
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Immunology in the medical area
Original languageEnglish
Pages (from-to)300-309
JournalImmunity, Inflammation and Disease
Volume5
Issue number3
Early online date2017 May 12
Publication statusPublished - 2017
Publication categoryResearch
Peer-reviewedYes