Burden of metastatic bone disease from genitourinary malignancies

Research output: Contribution to journalReview article


Bone metastases are common among patients with stage IV genitourinary cancers Most patients with bone metastases develop at least one debilitating and potentially life-limiting skeletal-related event These events are associated with increased medical expenses and decreased quality of life Current guidelines recommend screening for bone metastases in men with high-risk prostate cancer but guidance for screening and treatment of bone metastases from genitourinary cancers varies by country and setting Several bisphosphonates have been evaluated in the advanced genitourinary cancer setting Zoledronic acid has demonstrated efficacy in significantly reducing the risk of skeletal-related events in patients with bone metastases from a broad range of solid tumors including prostate renal and bladder cancers and is recommended for preserving bone health


  • Peter F. Mulders
  • Per-Anders Abrahamsson
  • Ronald M. Bukowski
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Urology and Nephrology


  • targeted therapy, related events, skeletal, genitourinary cancer, bisphosphonates, bone metastases
Original languageEnglish
Pages (from-to)1721-1733
JournalExpert Review of Anticancer Therapy
Issue number11
Publication statusPublished - 2010
Publication categoryResearch