Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways

Research output: Contribution to journalArticle

Bibtex

@article{f54d52bd9dbc43c19a9f54038bba6ccd,
title = "Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways",
abstract = "The early life human gut microbiota exerts life-long health effects on the host, but the mechanisms underpinning its assembly remain elusive. Particularly, the early colonization of Clostridiales from the Roseburia-Eubacterium group, associated with protection from colorectal cancer, immune- and metabolic disorders is enigmatic. Here, we describe catabolic pathways that support the growth of Roseburia and Eubacterium members on distinct human milk oligosaccharides (HMOs). The HMO pathways, which include enzymes with a previously unknown structural fold and specificity, were upregulated together with additional glycan-utilization loci during growth on selected HMOs and in co-cultures with Akkermansia muciniphila on mucin, suggesting an additional role in enabling cross-feeding and access to mucin O-glycans. Analyses of 4599 Roseburia genomes underscored the preponderance and diversity of the HMO utilization loci within the genus. The catabolism of HMOs by butyrate-producing Clostridiales may contribute to the competitiveness of this group during the weaning-triggered maturation of the microbiota.",
author = "Pichler, {Michael Jakob} and Chihaya Yamada and Bashar Shuoker and Camila Alvarez-Silva and Aina Gotoh and Leth, {Maria Louise} and Erwin Schoof and Toshihiko Katoh and Mikiyasu Sakanaka and Takane Katayama and Chunsheng Jin and Karlsson, {Niclas G.} and Manimozhiyan Arumugam and Shinya Fushinobu and {Abou Hachem}, Maher",
year = "2020",
doi = "10.1038/s41467-020-17075-x",
language = "English",
volume = "11",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group",
number = "1",

}