C4b-binding protein (C4BP) activates B cells through the CD40 receptor

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Abstract

We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.

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  • Immunology in the medical area
Original languageEnglish
Pages (from-to)837-848
JournalImmunity
Volume18
Issue number6
Publication statusPublished - 2003
Publication categoryResearch
Peer-reviewedYes