Cadmium-induced effects on bone in a population-based study of women

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Cadmium-induced effects on bone in a population-based study of women. / Akesson, A; Bjellerup, P; Lundh, Thomas; Lidfeldt, Jonas; Nerbrand, Christina; Samsioe, Göran; Skerfving, Staffan; Vahter, M.

In: Environmental Health Perspectives, Vol. 114, No. 6, 2006, p. 830-834.

Research output: Contribution to journalArticle

Harvard

Akesson, A, Bjellerup, P, Lundh, T, Lidfeldt, J, Nerbrand, C, Samsioe, G, Skerfving, S & Vahter, M 2006, 'Cadmium-induced effects on bone in a population-based study of women', Environmental Health Perspectives, vol. 114, no. 6, pp. 830-834. https://doi.org/10.1289/ehp.8763

APA

Akesson, A., Bjellerup, P., Lundh, T., Lidfeldt, J., Nerbrand, C., Samsioe, G., ... Vahter, M. (2006). Cadmium-induced effects on bone in a population-based study of women. Environmental Health Perspectives, 114(6), 830-834. https://doi.org/10.1289/ehp.8763

CBE

Akesson A, Bjellerup P, Lundh T, Lidfeldt J, Nerbrand C, Samsioe G, Skerfving S, Vahter M. 2006. Cadmium-induced effects on bone in a population-based study of women. Environmental Health Perspectives. 114(6):830-834. https://doi.org/10.1289/ehp.8763

MLA

Vancouver

Author

Akesson, A ; Bjellerup, P ; Lundh, Thomas ; Lidfeldt, Jonas ; Nerbrand, Christina ; Samsioe, Göran ; Skerfving, Staffan ; Vahter, M. / Cadmium-induced effects on bone in a population-based study of women. In: Environmental Health Perspectives. 2006 ; Vol. 114, No. 6. pp. 830-834.

RIS

TY - JOUR

T1 - Cadmium-induced effects on bone in a population-based study of women

AU - Akesson, A

AU - Bjellerup, P

AU - Lundh, Thomas

AU - Lidfeldt, Jonas

AU - Nerbrand, Christina

AU - Samsioe, Göran

AU - Skerfving, Staffan

AU - Vahter, M

PY - 2006

Y1 - 2006

N2 - High cadmium exposure is known to cause bone damage, but the association between low-level cadmium exposure and osteoporosis remains to be clarified. Using a population-based women's health survey in southern Sweden [Women's Health in the Lund Area (WHILA)] with no known historical cadmium contamination, we investigated cadmium-related effects on bone in 820 women (53-64 years of age). We measured cadmium in blood and urine and lead in blood, an array of markers of bone metabolism, and forearm bone mineral density (BMD). Associations were evaluated in multiple linear regression analysis including information on the possible confounders or effect modifiers: weight, menopausal status, use of hormone replacement therapy, age at menarche, alcohol consumption, smoking history, and physical activity. Median urinary cadmium was 0.52 mu g/L adjusted to density (0.67 mu g/g creatinine). After multivariate adjustment, BMD, parathyroid hormone, and urinary deoxypyridinoline (U-DPD) were adversely associated with concentrations of urinary cadmium (p < 0.05) in all subjects. These associations persisted in the group of never-smokers, which had the lowest cadmium exposure (mainly dietary). For U-DPD, there was a significant interaction between cadmium and menopause (p = 0.022). Our results suggest negative effects of low-level cadmium exposure on bone, possibly exerted via increased bone resorption, which seemed to be intensified after menopause. Based on the prevalence of osteoporosis and the low level of exposure, the observed effects, although slight, should be considered as early signals of potentially more adverse health effects.

AB - High cadmium exposure is known to cause bone damage, but the association between low-level cadmium exposure and osteoporosis remains to be clarified. Using a population-based women's health survey in southern Sweden [Women's Health in the Lund Area (WHILA)] with no known historical cadmium contamination, we investigated cadmium-related effects on bone in 820 women (53-64 years of age). We measured cadmium in blood and urine and lead in blood, an array of markers of bone metabolism, and forearm bone mineral density (BMD). Associations were evaluated in multiple linear regression analysis including information on the possible confounders or effect modifiers: weight, menopausal status, use of hormone replacement therapy, age at menarche, alcohol consumption, smoking history, and physical activity. Median urinary cadmium was 0.52 mu g/L adjusted to density (0.67 mu g/g creatinine). After multivariate adjustment, BMD, parathyroid hormone, and urinary deoxypyridinoline (U-DPD) were adversely associated with concentrations of urinary cadmium (p < 0.05) in all subjects. These associations persisted in the group of never-smokers, which had the lowest cadmium exposure (mainly dietary). For U-DPD, there was a significant interaction between cadmium and menopause (p = 0.022). Our results suggest negative effects of low-level cadmium exposure on bone, possibly exerted via increased bone resorption, which seemed to be intensified after menopause. Based on the prevalence of osteoporosis and the low level of exposure, the observed effects, although slight, should be considered as early signals of potentially more adverse health effects.

KW - women

KW - bone mineral density

KW - osteoporosis

KW - biochemical bone markers

KW - lead

KW - cadmium

U2 - 10.1289/ehp.8763

DO - 10.1289/ehp.8763

M3 - Article

VL - 114

SP - 830

EP - 834

JO - EHP Toxicogenomics

JF - EHP Toxicogenomics

SN - 1552-9924

IS - 6

ER -