Calcium metabolism and breast cancer risk

Research output: ThesisDoctoral Thesis (compilation)

Abstract

Emerging evidence suggests that calcium and its regulating hormones, i.e. vitamin D and parathyroid hormone (PTH), affect breast cancer risk.
The associations between serum calcium levels and breast cancer risk, between serum calcium levels and known risk factors of breast cancer, and between serum calcium levels and breast cancer aggressiveness were examined within the Malmö Preventive Project, a population-based cohort comprising 10,902 women. Serum calcium, 25-hydroxyvitamin D (25OHD) and PTH-levels were furthermore examined in relation to breast cancer risk in a nested case-control study comprising 764 breast cancer cases within the Malmö Diet and Cancer Study.
Serum calcium levels were positively associated with breast cancer risk in overweight/obese women. In premenopausal women, serum calcium was in one study negatively, and in one study positively, associated with breast cancer. Calcium was positively associated with breast cancer aggressiveness in overweight and/or premenopausal women. Premenopausal status and use of oral contraceptives and hormone-replacement therapy were negatively associated with serum calcium levels. BMI was significantly associated with serum calcium levels, with lean and overweight women having higher calcium levels than women with BMI between 20 and 25.
There was a weak, statistically non-significant, inverse association between 25OHD-levels and breast cancer risk. There was no evidence for any relation between PTH-levels and breast cancer.
It is concluded that serum calcium is positively associated with breast cancer risk and aggressiveness in overweight women. There may be a weak negative association between vitamin D and breast cancer risk, but this will have to be further examined.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Clinical Medicine

Keywords

  • calcium, breast cancer, vitamin D, body mass index, menopause, parathyroid hormone
Original languageEnglish
QualificationDoctor
Awarding Institution
Supervisors/Assistant supervisor
  • Jonas Manjer, Supervisor
  • Anne-Greth Bondeson, Supervisor
  • Lennart Bondeson, Supervisor
Award date2009 Mar 27
Publisher
  • Department of Clinical Sciences, Lund University
Print ISBNs978-91-86253-17-2
Publication statusPublished - 2009
Publication categoryResearch

Bibliographic note

Defence details Date: 2009-03-27 Time: 13:00 Place: Lilla aulan, Medicinskt Forskningscentrum, ing 59, UMAS, Malmö External reviewer(s) Name: Frisell, Jan Title: Professor Affiliation: Karolinska Hospital, Solna, Stockholm --- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200)

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Related research output

Martin Almquist, Jonas Manjer, Bondeson, L. & Bondeson, A-G., 2007, In : Cancer Causes and Control. 18, p. 595-602

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