Calpain activity in retinal degeneration.

Research output: Contribution to journalReview article

Abstract

Retinal degenerations such as retinitis pigmentosa (RP) or glaucoma are a major cause of blindness in humans. Understanding the mechanisms underlying the various types of retinal degeneration is a pre-requisite for the development of rational therapies for these diseases. Activation of the calcium dependent protease, calpain, has been suggested to play an important role in cell death in various neuronal tissues including the retina. Improved detection and analysis of calpain activity during degenerative processes is likely to expand the list of pathological conditions with calpain involvement. We give a short overview of the methods available for the detection of calpain activity, and briefly discuss properties of calpain inhibitors. We then discuss the role of calpains in different cell death mechanisms and review existing work on retinal degeneration and the possible involvement of calpains therein. The implication of calpains in retinal cell death raises the possibility to use calpain inhibitors to prevent or delay retinal degeneration. (c) 2006 Wiley-Liss, Inc.

Details

Authors
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurosciences

Keywords

  • photoreceptor, cell death, calcium, retinitis pigmentosa, calpastatin
Original languageEnglish
Pages (from-to)693-702
JournalJournal of Neuroscience Research
Volume85
Issue number4
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes