Cancer risk in systemic lupus: An updated international multi-centre cohort study

Research output: Contribution to journalArticle

Abstract

Objective: To update estimates of cancer risk in SLE relative to the general population. Methods: A multisite international SLE cohort was linked with regional tumor registries. Standardized incidence ratios (SIRs) were calculated as the ratio of observed to expected cancers. Results: Across 30 centres, 16,409 patients were observed for 121,283 (average 7.4) person years. In total, 644 cancers occurred. Some cancers, notably hematologic malignancies, were substantially increased (SIR 3.02, 95% confidence interval, CI, 2.48, 3.63), particularly non-Hodgkin's lymphoma, NHL (SIR 4.39, 95% CI 3.46, 5.49) and leukemia. In addition, increased risks of cancer of the vulva (SIR 3.78, 95% CI 1.52, 7.78), lung (SIR 1.30, 95% CI 1.04, 1.60), thyroid (SIR 1.76, 95% CI 1.13, 2.61) and possibly liver (SIR 1.87, 95% CI 0.97, 3.27) were suggested. However, a decreased risk was estimated for breast (SIR 0.73, 95% CI 0.61-0.88), endometrial (SIR 0.44, 95% CI 0.23-0.77), and possibly ovarian cancers (0.64, 95% Cl 0.34-1.10). The variability of comparative rates across different cancers meant that only a small increased risk was estimated across all cancers (SIR 1.14, 95% CI 1.05, 1.23). Conclusion: These data estimate only a small increased risk in SLE (versus the general population) for cancer over-all. However, there is clearly an increased risk of NHL and cancers of the vulva, lung, thyroid, and possibly liver. It remains unclear to what extent the association with NHL is mediated by innate versus exogenous factors. Similarly, the etiology of the decreased breast, endometrial, and possibly ovarian cancer risk is uncertain, though investigations are ongoing. (C) 2013 Elsevier Ltd. All rights reserved.

Details

Authors
  • Sasha Bernatsky
  • Rosalind Ramsey-Goldman
  • Jeremy Labrecque
  • Lawrence Joseph
  • Jean-Francois Boivin
  • Michelle Petri
  • Asad Zoma
  • Susan Manzi
  • Murray B. Urowitz
  • Dafna Gladman
  • Paul R. Fortin
  • Ellen Ginzler
  • Edward Yelin
  • Sang-Cheol Bae
  • Daniel J. Wallace
  • Steven Edworthy
  • Soren Jacobsen
  • Caroline Gordon
  • Mary Anne Dooley
  • Christine A. Peschken
  • John G. Hanly
  • Graciela S. Alarcon
  • Guillermo Ruiz-Irastorza
  • David Isenberg
  • Anisur Rahman
  • Torsten Witte
  • Cynthia Aranow
  • Diane L. Kamen
  • Kristjan Steinsson
  • Anca Askanase
  • Susan Barr
  • Lindsey A. Criswell
  • Gunnar Sturfelt
  • Neha M. Patel
  • Jean-Luc Senecal
  • Michel Zummer
  • Janet E. Pope
  • Stephanie Ensworth
  • Hani El-Gabalawy
  • Timothy McCarthy
  • Lene Dreyer
  • John Sibley
  • Ivan St Pierre
  • Ann E. Clarke
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Rheumatology and Autoimmunity

Keywords

  • Systemic lupus erythematosus, Epidemiology, Treatment, Disease activity
Original languageEnglish
Pages (from-to)130-135
JournalJournal of Autoimmunity
Volume42
Publication statusPublished - 2013
Publication categoryResearch
Peer-reviewedYes