Cancer therapy and risk of congenital malformations in children fathered by men treated for testicular germ-cell cancer: A nationwide register study

Research output: Contribution to journalArticle


Because of the potential mutagenic effects of chemo- and radiotherapy, there is concern regarding increased risk of congenital malformations (CMs) among children of fathers with cancer. Previous register studies indicate increased CM risk among children conceived after paternal cancer but lack data on oncological treatment. Increased CM risk was recently reported in children born before paternal cancer. This study aims to investigate whether anti-neoplastic treatment for testicular germ-cell cancer (TGCC) implies additional CM risk.


External organisations
  • Uppsala University
  • Karolinska Institutet
  • Skåne University Hospital
  • Norwegian University of Science and Technology
  • University Hospital of North Norway
  • UiT The Arctic University of Norway, Tromsø
  • St. Olav’s University Hospital
  • Danish Cancer Society Research Center
  • Copenhagen University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
  • Pediatrics
Original languageEnglish
Article numbere1002816
JournalPLoS Medicine
Issue number6
Publication statusPublished - 2019
Publication categoryResearch