Cancers in the first-degree relatives of children with brain tumours

Research output: Contribution to journalArticle

Abstract

We used the nationwide Swedish Family-Cancer Database with 2060 childhood brain tumours diagnosed in the period 1958-1996 to analyse the risk of this tumour by parental cancers and in siblings of childhood brain tumour probands. Groups of patients were compared by calculating standardized incidence ratios (SIRs) for brain tumours in offspring. 1.3% of brain tumour patients had a parent with nervous system cancer; SIRs were 2.4 and 1.88 for diagnostic ages < 5 and < 15 years, respectively. The data showed distinct patterns of familial risks for childhood brain tumours, the SIR was 10.26 for brain astrocytoma given a parent with meningioma. Parental colon cancer was associated with offspring ependymoma (SIR 3.70), and parental salivary gland cancers with offspring medulloblastoma (SIR 13.33, but two cases only). SIR for sibling nervous system cancer from childhood brain tumour probands was 3.55 up to age 61.

Details

Authors
External organisations
  • Karolinska Institutet
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • Adolescent, Adult, Astrocytoma/epidemiology, Brain Neoplasms/epidemiology, Child, Child, Preschool, Databases, Factual, Ependymoma/epidemiology, Female, Humans, Incidence, Male, Medulloblastoma/epidemiology, Middle Aged, Nuclear Family, Sweden/epidemiology
Original languageEnglish
Pages (from-to)407-11
Number of pages5
JournalBritish Journal of Cancer
Volume83
Issue number3
Publication statusPublished - 2000 Aug
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes