Cardiac output during targeted temperature management and renal function after out-of-hospital cardiac arrest

Research output: Contribution to journalArticle


Purpose: After resuscitation from out-of-hospital cardiac arrest (OHCA), renal injury and hemodynamic instability are common. We aimed to assess the association between low cardiac output during targeted temperature management (TTM) and acute kidney injury (AKI) after OHCA. Materials and methods: Single-center substudy of 171 patients included in the prospective, randomized TTM-trial. Hemodynamic evaluation was performed with serial measurements by pulmonary artery catheter. AKI was the primary endpoint and was defined according to the KDIGO-criteria. Results: Of 152 patients with available hemodynamic data, 49 (32%) had AKI and 21 (14%) had AKI with need for renal replacement therapy (RRT) in the first three days. During targeted temperature management, patients with AKI had higher heart rate (11 beats/min, pgroup < 0.0001), higher mean arterial pressure (MAP) (4 mmHg, pgroup = 0.001) and higher lactate (1 mmol/L, pgroup < 0.0001) compared to patients without AKI. However, there was no difference in cardiac index (pgroup = 0.25). In a multivariate logistic regression model, adjusting for potential confounders, MAP (p = .03), heart rate (p = .01) and lactate (p = .006), but not cardiac output, were independently associated with AKI. Conclusions: Blood pressure, heart rate and lactate, but not cardiac output, during 24 h of TTM were associated with AKI in comatose OHCA-patients.


  • Johannes Grand
  • John Bro-Jeppesen
  • Christian Hassager
  • Malin Rundgren
  • Matilde Winther-Jensen
  • Jakob Hartvig Thomsen
  • Niklas Nielsen
  • Michael Wanscher
  • Jesper Kjærgaard
External organisations
  • Copenhagen University Hospital
  • Skåne University Hospital
  • Helsingborg Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cardiac and Cardiovascular Systems


  • Acute kidney injury, Cardiac arrest, Cardiac output, Dialysis, Hemodynamic, Post cardiac arrest syndrome
Original languageEnglish
Pages (from-to)65-73
Number of pages9
JournalJournal of Critical Care
Publication statusPublished - 2019 Dec
Publication categoryResearch