Cartilage mechanics and morphology, synovitis and proteoglycan fragments in rabbit joint fluid after prosthetic meniscal substitution

Research output: Contribution to journalArticle

Abstract

The effects of meniscal substitution with a Dacron® or Teflon® prosthesis on rabbit knee-joint cartilage were studied by indentation tests, gross and histological inspection, analysis of proteoglycan fragments in joint fluid and an evaluation of synovial changes. Cartilage mechanics and cartilage morphology were similarly abnormal after meniscectomy and meniscal substitution. The elevated concentrations of proteoglycan fragments in joint fluid and the more severe synovial changes in joints with a meniscal substitute, as compared to meniscectomy, probably resulted from irritation of the artificial implant, but also reflected the remaining effects from the necessary bone drilling. In this short-term experiment, the use of an artificial meniscal substitute could not prevent cartilage degeneration after meniscectomy.

Details

Authors
Organisations
External organisations
  • Linköping University Hospital
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Orthopedics

Keywords

  • Dacron®, Knee-joint prosthesis, meniscectomy, proteoglycan, synovitis, Teflon®
Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalBiomaterials
Volume14
Issue number3
Publication statusPublished - 1993
Publication categoryResearch
Peer-reviewedYes