C-band heteromorphism in breast cancer patients

Research output: Contribution to journalArticle

Abstract

The pattern of heteromorphism in the C-band-positive constitutive heterochromatin of human chromosomes #1, #9, and #16 was studied in peripheral lymphocytes of 54 breast cancer patients and 78 control individuals. The parameters of the heterochromatic regions analyzed were relative size, symmetry-asymmetry within homologous pairs, and prevalence of inversions. Significant differences between the two groups were found in C-band size of chromosomes #1, #9, and #16 and in incidence of inversions on chromosomes #1 and #9. Significant differences were noted between premenopausal and postmenopausal cancer patients in regard to inversions on chromosome #9 and between familial and sporadic patients in regard to C-band size on chromosome #16.

Details

Authors
Organisations
External organisations
  • Saint-Louis Hospital, Paris
  • Skåne University Hospital
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology
Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalCancer Genetics and Cytogenetics
Volume18
Issue number1
Publication statusPublished - 1985 Jan 1
Publication categoryResearch
Peer-reviewedYes