CD40 expression identifies a prognostically favourable subgroup of diffuse large B-cell lymphoma.

Research output: Contribution to journalArticle

Abstract

In order to confirm our earlier findings of the prognostic effects of CD23 and CD40 expression in diffuse large B-cell lymphoma (DLBCL), possibly due to association with the germinal center (GC) phenotype and/or an increased autologous tumour response, tumour specimens from 125 patients with de novo DLBCL were investigated for immunohistochemical expression of CD23, CD40, BCL6, CD10, MUM1, CD4 and CD8. CD40 was positive in 64% and was associated with improved overall survival (p = 0.03). A GC phenotype was present in 47%, and was also associated with a better overall survival (p = 0.006) but did not correlate with CD40-expression. There was no correlation between amount of tumour infiltrating T-cells and CD40-positivity. CD23 was positive in 10% and expression did not correlate with prognosis. In conclusion, the prognostic effect of CD40 expression was confirmed, but did not correlate with GC-phenotype or T-cell infiltration.

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Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Cancer and Oncology

Keywords

  • DLBCL, CD40, prognosis, GC-phenotype, CD4, CD8
Original languageEnglish
Pages (from-to)1774-1779
JournalLeukemia & Lymphoma
Volume48
Issue number9
Publication statusPublished - 2007
Publication categoryResearch
Peer-reviewedYes

Related research output

Linderoth, J., 2007, Department of Oncology, Clinical Sciences, Lund University. 71 p.

Research output: ThesisDoctoral Thesis (compilation)

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