CEACAM1 inhibits Toll-like receptor 2-triggered antibacterial responses of human pulmonary epithelial cells

Research output: Contribution to journalArticle

Abstract

Although Moraxella catarrhalis and Neisseria meningitidis are important human pathogens, they often colonize the human respiratory tract without causing overt clinical symptoms. Both pathogens express structurally unrelated proteins that share the ability to stimulate the adhesion molecule CEACAM1 expressed on human cells. Here we demonstrate that the interaction of CEACAM1 with ubiquitous surface protein A1 expressed on M. catarrhalis or with opacity-associated proteins on N. meningitidis resulted in reduced Toll-like receptor 2-initiated transcription factor NF-kappa B-dependent inflammatory responses of primary pulmonary epithelial cells. These inhibitory effects were mediated by tyrosine phosphorylation of the immunoreceptor tyrosine-based inhibitory motif of CEACAM1 and by recruitment of the phosphatase SHP-1, which negatively regulated Toll-like receptor 2-dependent activation of the phosphatidylinositol 3-OH kinase-Akt kinase pathway. Our results identify a CEACAM1-dependent immune-evasion strategy.

Details

Authors
  • Hortense Slevogt
  • Solveig Zabel
  • Bastian Opitz
  • Andreas Hocke
  • Julia Eitel
  • Philippe D. N'Guessan
  • Lothar Lucka
  • Kristian Riesbeck
  • Wolfgang Zimmermann
  • Janine Zweigner
  • Bettina Temmesfeld-Wollbrueck
  • Norbert Suttorp
  • Bernhard B. Singer
Organisations
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Microbiology in the medical area
Original languageEnglish
Pages (from-to)1270-1278
JournalNature Immunology
Volume9
Issue number11
Publication statusPublished - 2008
Publication categoryResearch
Peer-reviewedYes