Cellular immune dysfunction in immune thrombocytopenia (ITP)

Research output: Contribution to journalArticle

Abstract

Over the past decades, a wealth of information has been reported about the pathogenic features of immune thrombocytopenia (ITP). To this day, however, it is unclear whether the immune abnormalities associated with ITP play causative roles in the disease or are secondary epiphenomena brought on by the inflammatory processes that are associated with the disorder. Like the majority of all autoimmune diseases, ITP is an organ-specific disease and abnormalities in immune cell types, such as antigen-presenting cells (APC), T cells and B cells have been shown to play some sort of role in the initiation and/or perpetuation of the disease. This review will discuss recent advances in understanding three immune cells important in ITP pathophysiology: APC, T cells and B cells, and will review how they interact with each other to initiate and perpetuate ITP, particularly the chronic form of the disorder. It will also focus on new data related to the genetics of the disorder and discuss relevant animal models of ITP.

Details

Authors
External organisations
  • St. Michael's Hospital
  • University of Toronto
Research areas and keywords

Keywords

  • Animals, Antigen-Presenting Cells, B-Lymphocytes, Disease Models, Animal, Humans, Immunity, Cellular, Purpura, Thrombocytopenic, Idiopathic, Signal Transduction, T-Lymphocyte Subsets, Journal Article, Research Support, Non-U.S. Gov't, Review
Original languageEnglish
Pages (from-to)10-23
Number of pages14
JournalBritish Journal of Haematology
Volume163
Issue number1
Publication statusPublished - 2013 Oct
Publication categoryResearch
Peer-reviewedYes
Externally publishedYes