Cellular immune dysfunction in immune thrombocytopenia (ITP)

Research output: Contribution to journalArticle

Standard

Cellular immune dysfunction in immune thrombocytopenia (ITP). / McKenzie, Christopher G J; Guo, Li; Freedman, John; Semple, John W.

In: British Journal of Haematology, Vol. 163, No. 1, 10.2013, p. 10-23.

Research output: Contribution to journalArticle

Harvard

APA

CBE

MLA

Vancouver

Author

McKenzie, Christopher G J ; Guo, Li ; Freedman, John ; Semple, John W. / Cellular immune dysfunction in immune thrombocytopenia (ITP). In: British Journal of Haematology. 2013 ; Vol. 163, No. 1. pp. 10-23.

RIS

TY - JOUR

T1 - Cellular immune dysfunction in immune thrombocytopenia (ITP)

AU - McKenzie, Christopher G J

AU - Guo, Li

AU - Freedman, John

AU - Semple, John W

N1 - © 2013 John Wiley & Sons Ltd.

PY - 2013/10

Y1 - 2013/10

N2 - Over the past decades, a wealth of information has been reported about the pathogenic features of immune thrombocytopenia (ITP). To this day, however, it is unclear whether the immune abnormalities associated with ITP play causative roles in the disease or are secondary epiphenomena brought on by the inflammatory processes that are associated with the disorder. Like the majority of all autoimmune diseases, ITP is an organ-specific disease and abnormalities in immune cell types, such as antigen-presenting cells (APC), T cells and B cells have been shown to play some sort of role in the initiation and/or perpetuation of the disease. This review will discuss recent advances in understanding three immune cells important in ITP pathophysiology: APC, T cells and B cells, and will review how they interact with each other to initiate and perpetuate ITP, particularly the chronic form of the disorder. It will also focus on new data related to the genetics of the disorder and discuss relevant animal models of ITP.

AB - Over the past decades, a wealth of information has been reported about the pathogenic features of immune thrombocytopenia (ITP). To this day, however, it is unclear whether the immune abnormalities associated with ITP play causative roles in the disease or are secondary epiphenomena brought on by the inflammatory processes that are associated with the disorder. Like the majority of all autoimmune diseases, ITP is an organ-specific disease and abnormalities in immune cell types, such as antigen-presenting cells (APC), T cells and B cells have been shown to play some sort of role in the initiation and/or perpetuation of the disease. This review will discuss recent advances in understanding three immune cells important in ITP pathophysiology: APC, T cells and B cells, and will review how they interact with each other to initiate and perpetuate ITP, particularly the chronic form of the disorder. It will also focus on new data related to the genetics of the disorder and discuss relevant animal models of ITP.

KW - Animals

KW - Antigen-Presenting Cells

KW - B-Lymphocytes

KW - Disease Models, Animal

KW - Humans

KW - Immunity, Cellular

KW - Purpura, Thrombocytopenic, Idiopathic

KW - Signal Transduction

KW - T-Lymphocyte Subsets

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

KW - Review

U2 - 10.1111/bjh.12480

DO - 10.1111/bjh.12480

M3 - Article

VL - 163

SP - 10

EP - 23

JO - British Journal of Haematology

T2 - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 1

ER -