Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology

Research output: Contribution to journalArticle


We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.


  • Susanna Ranta
  • Ruta Tuckuviene
  • Anne Makipernaa
  • Birgitte K. Albertsen
  • Tony Frisk
  • Ulf Tedgård
  • Olafur G. Jonsson
  • Kaie Pruunsild
  • Nadine Gretenkort
  • Maria Winther Gunnes
  • Sonata Saulyte Trakymiene
  • Thomas Frandsen
  • Mats Heyman
  • Ellen Ruud
  • Jon Helgestad
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Hematology


  • cerebral sinovenous thrombosis, acute leukaemia, paediatric
Original languageEnglish
Pages (from-to)547-552
JournalBritish Journal of Haematology
Issue number4
Publication statusPublished - 2015
Publication categoryResearch