Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology

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Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology. / Ranta, Susanna; Tuckuviene, Ruta; Makipernaa, Anne; Albertsen, Birgitte K.; Frisk, Tony; Tedgård, Ulf; Jonsson, Olafur G.; Pruunsild, Kaie; Gretenkort, Nadine; Gunnes, Maria Winther; Trakymiene, Sonata Saulyte; Frandsen, Thomas; Heyman, Mats; Ruud, Ellen; Helgestad, Jon.

In: British Journal of Haematology, Vol. 168, No. 4, 2015, p. 547-552.

Research output: Contribution to journalArticle

Harvard

Ranta, S, Tuckuviene, R, Makipernaa, A, Albertsen, BK, Frisk, T, Tedgård, U, Jonsson, OG, Pruunsild, K, Gretenkort, N, Gunnes, MW, Trakymiene, SS, Frandsen, T, Heyman, M, Ruud, E & Helgestad, J 2015, 'Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology', British Journal of Haematology, vol. 168, no. 4, pp. 547-552. https://doi.org/10.1111/bjh.13162

APA

CBE

Ranta S, Tuckuviene R, Makipernaa A, Albertsen BK, Frisk T, Tedgård U, Jonsson OG, Pruunsild K, Gretenkort N, Gunnes MW, Trakymiene SS, Frandsen T, Heyman M, Ruud E, Helgestad J. 2015. Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology. British Journal of Haematology. 168(4):547-552. https://doi.org/10.1111/bjh.13162

MLA

Vancouver

Author

Ranta, Susanna ; Tuckuviene, Ruta ; Makipernaa, Anne ; Albertsen, Birgitte K. ; Frisk, Tony ; Tedgård, Ulf ; Jonsson, Olafur G. ; Pruunsild, Kaie ; Gretenkort, Nadine ; Gunnes, Maria Winther ; Trakymiene, Sonata Saulyte ; Frandsen, Thomas ; Heyman, Mats ; Ruud, Ellen ; Helgestad, Jon. / Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology. In: British Journal of Haematology. 2015 ; Vol. 168, No. 4. pp. 547-552.

RIS

TY - JOUR

T1 - Cerebral sinus venous thromboses in children with acute lymphoblastic leukaemia - a multicentre study from the Nordic Society of Paediatric Haematology and Oncology

AU - Ranta, Susanna

AU - Tuckuviene, Ruta

AU - Makipernaa, Anne

AU - Albertsen, Birgitte K.

AU - Frisk, Tony

AU - Tedgård, Ulf

AU - Jonsson, Olafur G.

AU - Pruunsild, Kaie

AU - Gretenkort, Nadine

AU - Gunnes, Maria Winther

AU - Trakymiene, Sonata Saulyte

AU - Frandsen, Thomas

AU - Heyman, Mats

AU - Ruud, Ellen

AU - Helgestad, Jon

PY - 2015

Y1 - 2015

N2 - We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.

AB - We present a prospective multicentre cohort of 20 children with acute lymphoblastic leukaemia (ALL) and cerebral sinus venous thrombosis (CSVT). The study covers a period of 5years and comprises 1038 children treated according to the Nordic Society of Paediatric Haematology and Oncology (NOPHO) ALL 2008 protocol. The cumulative incidence of CSVT was 2%. Sixteen of the thromboses were related to asparaginase and 16 to steroids. Most CSVTs occurred in the consolidation phase. Nearly all were treated with low molecular weight heparin without bleeding complications. Mortality related to CSVT directly or indirectly was 10%, emphasizing the importance of this complication.

KW - cerebral sinovenous thrombosis

KW - acute leukaemia

KW - paediatric

U2 - 10.1111/bjh.13162

DO - 10.1111/bjh.13162

M3 - Article

VL - 168

SP - 547

EP - 552

JO - British Journal of Haematology

T2 - British Journal of Haematology

JF - British Journal of Haematology

SN - 0007-1048

IS - 4

ER -