Cerebrospinal fluid Alzheimer's disease biomarkers across the spectrum of lewy body diseases: Results from a large multicenter cohort

Research output: Contribution to journalArticle

Abstract

Background: Concomitant Alzheimer's disease (AD) pathology is observed in Lewy body diseases (LBD), but the clinical impact is unknown. Only a few biomarker studies in LBD exist and have included small cohorts from single centers. Objective: We aimed to evaluate the prevalence of abnormal cerebrospinal fluid (CSF) AD biomarkers across the spectrum of LBD in a large multicenter cohort and to assess whether an AD biomarker profile was associated with demographic and clinical differences in dementia with Lewy bodies (DLB). Methods:We included 375 DLB patients, 164 Parkinson's disease (PD) patients without dementia, and 55 PD patients with dementia (PDD) from 10 centers. CSF amyloid-beta42 (Aβ42), total tau (t-tau), and phosphorylated tau (p-tau) values were dichotomized as abnormal or normal according to locally available cut-off values. A CSF AD profile was defined as abnormal Aβ42 combined with abnormal t-tau and/or p-tau. Results: A substantial proportion of DLB patients had abnormal values for CSF Aβ42, t-tau, and p-tau, while abnormal values were uncommon in PD without dementia. Patients with PDD had values in between. A CSF AD profile was observed in 25% of DLB patients, compared with only 9% of PDD and 3% of PD without dementia.Within DLB, patients with a CSF AD profile were older, more often female, performed worse on the Mini-Mental State Examination, and had shorter disease duration compared with patients with normal CSF. Conclusion: A CSF AD profile is more common in DLB compared with PDD and PD, and is associated with more severe cognitive impairment in DLB.

Details

Authors
  • Inger Van Steenoven
  • Dag Aarsland
  • Daniel Weintraub
  • Elisabet Londos
  • Frederic Blanc
  • Wiesje M. Van Der Flier
  • Charlotte E. Teunissen
  • Brit Mollenhauer
  • Tormod Fladby
  • Milica G. Kramberger
  • Laura Bonanni
  • Afina W. Lemstra
Organisations
External organisations
  • Amsterdam UMC - Vrije Universiteit Amsterdam
  • Stavanger University Hospital
  • University of Pennsylvania
  • University Hospital Of Strasbourg
  • University of Göttingen
  • Akershus University Hospital
  • University of Chieti-Pescara
  • University Medical Centre Ljubljana
Research areas and keywords

Subject classification (UKÄ) – MANDATORY

  • Neurology

Keywords

  • Amyloid beta-protein (1-42), Biomarkers, Cerebrospinal fluid, Dementia with Lewy bodies, Lewy body disease, Tau protein
Original languageEnglish
Pages (from-to)287-295
Number of pages9
JournalJournal of Alzheimer's Disease
Volume54
Issue number1
Publication statusPublished - 2016 Aug 23
Publication categoryResearch
Peer-reviewedYes